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Merck

I1007

Sigma-Aldrich

6-(Iodoacetamido)hexanoic acid N-hydroxysuccinimide ester

powder

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About This Item

经验公式(希尔记法):
C12H17IN2O5
分子量:
396.18
MDL號碼:
分類程式碼代碼:
12171500

形狀

powder

溶解度

methanol: 50 mg/mL
DMF: soluble

儲存溫度

−20°C

SMILES 字串

ICC(=O)NCCCCCC(=O)ON1C(=O)CCC1=O

應用

A heterobifunctional cross-linking reagent containing an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 7.5 (7.0-8.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 9-atom linker.

注意

碘乙酰基具有光敏性。

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E S Rector et al.
Journal of immunological methods, 24(3-4), 321-336 (1978-01-01)
A novel procedure for the synthesis of well-defined protein-protein conjugates is described using ovalbumin (OA) and IgG as test proteins. This procedure involves the highly selective and rapid reaction of alkyl halide and sulfhydryl groups, which have been grafted, respectively

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