推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunohistochemistry: 1:50- 1:200
免疫原序列
EGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWE
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... BST1(683)
一般說明
The gene BST1 (bone marrow stromal cell antigen 1) is mapped to human chromosome 4p15. It belongs to the CD38 (cluster of differentiation 38) gene family and the encoded protein is a member of the NADase (NAD+ glycohydrolase)/ADP (adenosine diphosphate)-ribosyl cyclase family. The BST1 gene encodes a glycosylphosphatidylinositol-anchored protein. It is present in myeloid, endothelial and mesothelial cells as well as in epithelial ovarian cancer cells.
免疫原
bone marrow stromal cell antigen 1 recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
BST1 (bone marrow stromal cell antigen 1) was recognized as a stromal and myeloid surface glycoprotein. It is responsible for the cleavage of extracellular nicotinamide adenine dinucleotide (NAD+), resulting in ADP ribose (ADPR) and cyclic ADPR (cADPR). BST1 helps in the transduction of intracellular signals by associating with transmembrane molecules. It is involved in leukocyte adhesion, migration and diapedesis. Mutations in the BST1 gene are associated with susceptibility to Parkinson′s disease.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST85380
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A deletion involving CD38 and BST1 results in a fusion transcript in a patient with autism and asthma.
A deletion involving CD38 and BST1 results in a fusion transcript in a patient with autism and asthma.
A deletion involving CD38 and BST1 results in a fusion transcript in a patient with autism and asthma.
Ceroni F, et al.
Autism Research : Official Journal of the International Society for Autism Research, 7, 254-263 (2014)
Association between bone marrow stromal cell antigen 1 gene polymorphisms and the susceptibility to Parkinson's disease: a meta-analysis.
Wang S, et al.
Neuroscience Letters, 599, 120-124 (2015)
Binding of CD157 protein to fibronectin regulates cell adhesion and spreading.
Morone S, et al.
The Journal of Biological Chemistry, 289, 15588-15601 (2014)
Emiko Aomatsu et al.
Scientific reports, 4, 3652-3652 (2014-01-15)
Human mesenchymal stem cells (hMSCs) remodel or regenerate various tissues through several mechanisms. Here, we identified the hMSC-secreted protein SCRG1 and its receptor BST1 as a positive regulator of self-renewal, migration, and osteogenic differentiation. SCRG1 and BST1 gene expression decreased
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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