推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunohistochemistry: 1:20- 1:50
免疫原序列
SSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQ
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CYP1B1(1545)
一般說明
The Cytochrome P4501B1 (CYP1B1) gene with three exons and two introns is mapped to human chromosome 2p21-22. The 543 amino acid protein encoded by this gene is expressed mainly in the adrenals, ovary. The protein is a member of cytochrome P4501, a subfamily of CYP1 family .
CYP1B1 is deprived of a consensus TATA box in the promoter region and it is characterized with nine tetrachlorodibenzo-p-dioxin (TCDD) responsive enhancer core binding motifs present within a 2.5kb pair genomic fragment of the transcription initiation start site.
CYP1B1 is deprived of a consensus TATA box in the promoter region and it is characterized with nine tetrachlorodibenzo-p-dioxin (TCDD) responsive enhancer core binding motifs present within a 2.5kb pair genomic fragment of the transcription initiation start site.
免疫原
cytochrome P450, family 1, subfamily B, polypeptide 1 recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
Tissue distribution pattern analysis shows that cytochrome P4501B1 (CYP1B1) plays a vital role in metabolism of xenobiotics and possibly steroid hormones. CYP1B1 might be responsible for the metabolism of biologically active molecule associated with eye development. Any truncating mutation of the gene coding for this protein causes primary congenital glaucoma. Isoflavone genistein stimulates the gene expression of CYP1B1, which plays a vital role in human breast cancer development and progression. CYP1B1 enzyme catalyzes the conversion of pro-carcinogens to carcinogens and also facilitates estrogen metabolism. Single nucleotide polymorphism (SNP) of CYP1B1 might enhance susceptibility and pathological development of hepatocellular carcinoma (HCC) in Chinese population.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST86682
外觀
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells.
Wei YK
Journal of Environmental Pathology, Toxicology and Oncology, 34(2), 153-159 (2015)
Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21.
Human Molecular Genetics, 6(4), 641-647 (1997)
Polymorphisms of the CYP1B1 gene and hepatocellular carcinoma risk in a Chinese population.
Liu F
Gene, 564(1), 14-20 (2015)
Isolation and characterization of the human cytochrome P450 CYP1B1 gene.
Tang YM
The Journal of Biological Chemistry, 271(45), 28324-28330 (1996)
Mateusz Kurzawski et al.
Pharmacological reports : PR, 64(4), 927-939 (2012-10-23)
Expression of drug-metabolizing enzymes and drug transporters in liver is mainly regulated by a system of nuclear receptors. The aim of the current study was to investigate the expression of nuclear receptors, as well as these enzymes and transporters, in
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