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Merck
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文件

H5136

Sigma-Aldrich

氢吗啡酮 盐酸盐

别名:

(5α)-4,5-Epoxy-3-hydroxy-17-methyl-morphinan-6-one hydrochloride, Hydromorphone HCl

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About This Item

经验公式（希尔记法）:
C17H19NO3 · HCl
CAS号:
71-68-1
分子量:
321.80
EC號碼:
200-762-6
MDL號碼:
MFCD03427563
分類程式碼代碼:
12352200
PubChem物質ID:
24895673
NACRES:
NA.77

藥物控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

技術

HPLC: suitable
gas chromatography (GC): suitable

溶解度

H2O: >10 mg/mL

應用

forensics and toxicology
veterinary

SMILES 字串

OC1=C(O2)C3=C(C[C@@H]4[C@@]5([H])[C@@]3([C@]2([H])C(CC5)=O)CCN4C)C=C1.[H]Cl

InChI

1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2,4,10-11,16,19H,3,5-8H2,1H3;1H/t10-,11+,16-,17-;/m0./s1

InChI 密鑰

XHILEZUETWRSHC-NRGUFEMZSA-N

基因資訊

human ... OPRM1(4988)

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生化／生理作用

Narcotic opiate analgesic; μ opioid receptor agonist.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302,H336

防範說明

P301 + P312 + P330

危險分類

Acute Tox. 4 Oral - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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H M Korani et al.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 28(6), 409-416 (2015-10-10)
Evaluate variability associated with assessing changes in the position of uncemented femoral stems. Stem level, canal fill, stem angle, and version angle were measured on craniocaudal horizontal beam (CCHB) and open leg lateral (OLL) radiographic projections of the femur of
D L Cichewicz et al.
The Journal of pharmacology and experimental therapeutics, 289(2), 859-867 (1999-04-24)
The antinociceptive effects of various mu opioids given p.o. alone and in combination with Delta-9-tetrahydrocannabinol (Delta9-THC) were evaluated using the tail-flick test. Morphine preceded by Delta9-THC treatment (20 mg/kg) was significantly more potent than morphine alone, with an ED50 shift
E M Costa et al.
Life sciences, 50(1), 73-81 (1992-01-01)
SH-SY5Y (human neuroblastoma) cultured cells, known to have mu-opioid receptors, have been used to assess and compare the ability of eight representative mu-selective compounds from diverse opioid families to recognize and activate these receptors. A wide range of receptor affinities
P Sacerdote et al.
British journal of pharmacology, 121(4), 834-840 (1997-06-01)
1. Although it is well known that morphine induces significant immunosuppression, the potential immunosuppressive activity of morphine derived drugs commonly used in the treatment of pain (codeine, hydromorphone, oxycodone) has never been evaluated. 2. We evaluated in the mouse the

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