生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~30 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
western blot: 1-2 μg/mL using Jurkat cell lysates
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HOXB8(3218)
一般描述
Homeobox B8 (HOXB8) protein belongs to the homeobox (HOX) containing complex. HOXB8 gene is expressed in the spinal cord during embryonic development. The HOXB8 gene is located on the human chromosome at 17q21.32.
特异性
Anti-HOXB8 (C-terminal) recognizes human HOXB8 (also known as Hox-2D, Hox-2).
应用
Anti-HOXB8 (C-terminal) antibody produced in rabbit may be used in immunoblotting.
生化/生理作用
Overexpression of the homeobox B8 (HOXB8) gene is identified as a cause for leukemia. The encoded protein prevents myeloid differentiation by a mechanism that requires interaction with pre‐B‐cell leukemia homeobox (Pbx) protein.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Jan C Holstege et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(17), 6338-6343 (2008-04-24)
Although Hox gene expression has been linked to motoneuron identity, a role of these genes in development of the spinal sensory system remained undocumented. Hoxb genes are expressed at high levels in the dorsal horn of the spinal cord. Hoxb8
P S Knoepfler et al.
Oncogene, 20(39), 5440-5448 (2001-09-26)
HoxB8 was the first homeobox gene identified as a cause of leukemia. In murine WEHI3B acute myeloid leukemia (AML) cells, proviral integration leads to the expression of both HoxB8 and Interleukin (IL-3). Enforced expression of HoxB8 blocks differentiation of factor-dependent
Joy M Greer et al.
Neuron, 33(1), 23-34 (2002-01-10)
Repertoires of grooming behaviors critical to survival are exhibited by most animal species, including humans. Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair
Nobumoto Tomioka et al.
Cancer genetics and cytogenetics, 201(1), 6-14 (2010-07-17)
Unlike the case with some other solid tumors, whole genome array screening has not revealed prognostic genetic aberrations in primary gastric cancer. Comparative genomic hybridization (CGH) using bacterial artificial chromosome (BAC) arrays for 56 primary gastric cancers resulted in identification
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