生物源
chicken
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
製造商／商標名
Genway 15-288-21980B
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CARD14(79092)
一般說明
The gene CARD14 (caspase recruitment domain family member 14) encodes a member of the MAGUK (membrane-associated guanylate kinase) family of proteins. These proteins are scaffold proteins that participate in the assembly of multiprotein complexes at certain sites on the plasma membrane. The encoded protein contains an N-terminal CARD domain, a central coiled-coil domain, and a tripartite domain comprising of a PDZ (PSD-95, Dlg1, ZO-1) domain, an Src (Sarcoma) homology 3 domain, and a GUK (Guanylate kinase) domain at the C-terminus. The gene is mapped to human chromosome 17q25. It is mainly expressed in the basal and suprabasal layers of healthy skin epidermis.
免疫原
Immunogen Sequence: GI # 16507955, sequence 221-330
Recombinant caspase recruitment domain protein 14 isoform 2
生化／生理作用
The gene CARD14 (caspase recruitment domain family member 14) encodes a nuclear factor that contains a CARD domain involved in binding to the CARD domain of BCL10 (B cell leukemia 10), a protein involved in the activation of NF-κB through the IKK complex, and positive regulation of apoptosis. Mutations in this gene are associated with familial pityriasis rubra pilaris, a papulosquamous disorder phenotypically related to psoriasis. It also activates p38 and JNK MAP (c-Jun N-terminal kinase mitogen-activated protein) kinase pathways via association with paracaspase-1 (PCASP-1), also referred to as MALT1, which can serve as a therapeutic target in psoriasis.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
PSORS2 is due to mutations in CARD14.
Jordan CT
American Journal of Human Genetics, 90 , 784-795 (2012)
Familial pityriasis rubra pilaris is caused by mutations in CARD14.
Fuchs-Telem D
American Journal of Human Genetics, 91, 163-170 (2012)
J Bertin et al.
The Journal of biological chemistry, 276(15), 11877-11882 (2001-03-30)
The caspase recruitment domain (CARD) is a protein-binding module that mediates the assembly of CARD-containing proteins into apoptosis and NF-kappaB signaling complexes. We report here that CARD protein 11 (CARD11) and CARD protein 14 (CARD14) are novel CARD-containing proteins that
Inna S Afonina et al.
EMBO reports, 17(6), 914-927 (2016-04-27)
Mutations in CARD14 have recently been linked to psoriasis susceptibility. CARD14 is an epidermal regulator of NF-κB activation. However, the ability of CARD14 to activate other signaling pathways as well as the biochemical mechanisms that mediate and regulate its function
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