GW21046

Anti-CCR2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• 别名: Anti-Chemokine (C-C motif) receptor 2 isoform A, Anti-MCP-1 receptor
• MDL编号: MFCD01864606
• UNSPSC代码: 12352203

属性

• 生物来源: chicken
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 种属反应性: human
• 制造商/商品名称: Genway 15-288-21046
• 技术: western blot: suitable
• NCBI登记号: NP_000638.1
• UniProt登记号: O95950
• 运输: wet ice
• 储存温度: −20°C
• 基因信息: human ... CCR2(1231)

说明

一般描述

CCR2 (chemokine (C-C motif) receptor 2) belongs to the chemokine receptor family, which are small (8-10kDa) G-protein coupled receptors (GPCR). This family is subdivided into four families called CC, CXC, CX3C and XC. CCR2 belongs to the CC family, and has its ligand-binding domain in its exoplasmic N-terminal. Its C-terminal is involved in intracellular signaling. It is constitutively expressed by monocytes, and is found on T-cells, naïve B-cells, NK (natural killer) cells, dendritic cells and basophils.

免疫原

Immunogen Sequence: GI # 4502633, sequence 1-45

Recombinant chemokine (C-C motif) receptor 2 isoform A

应用

Anti-CCR2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
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生化/生理作用

C-C chemokine receptor type 2 (CCR2) is an important chemokine for monocyte aggregation and transendothelial monocyte migration. CCR2 plays an important role in extravasation and transmigration of monocytes under inflammatory conditions. It is involved in the growth and invasion of prostate cancer (PCa). CCR2 expression is very important for CCL2-induced proliferation and invasion of PC-3M cells. CCR2 can also act as a promising molecular target for prevention of PCa growth and metastasis.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)