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Merck

GW21024

Sigma-Aldrich

Anti-ADCY6 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

别名:

Anti-Adenylate cyclase type 6, Anti-KIAA0422

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

chicken

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human

製造商/商標名

Genway 15-288-21024

技術

western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... ADCY6(112)

免疫原

Immunogen Sequence: GI # 10181096, sequence 1-121
Recombinant adenylate cyclase 6 isoform a

應用

Anti-ADCY6 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

Adenylate cyclase type 6 is an enzyme encoded by the ADCY6 gene in humans. It is a critical regulator of metabolic and cardiovascular function. It is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types. It is localized in lipid rafts of COS-7 cells (expressing caveolin-1). Both the C1 and C2 domains of AC6 play a role in targeting AC6 to lipid rafts.

外觀

Solution in phosphate buffered saline containing 0.02% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Gary J Hodges et al.
The Journal of pharmacology and experimental therapeutics, 335(2), 451-457 (2010-08-25)
Adenylyl cyclase (ADCY) is a critical regulator of metabolic and cardiovascular function. We have identified a genetic variant (A674S) in ADCY isoform 6 (ADCY6). Subsequent studies demonstrated that the expression of this ADCY6 variant paralleled an increase in adenylyl cyclase-mediated
Muthusamy Thangavel et al.
Cellular signalling, 21(2), 301-308 (2008-11-15)
Previous data has shown that adenylyl cyclase type 6 (AC6) is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types while certain other isoforms of AC are excluded from these microdomains. The mechanism by which

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