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Merck

G4626

Sigma-Aldrich

L -氧化谷胱甘肽 二钠盐

≥98%, suitable for HPLC

别名:

GSSG

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About This Item

经验公式(希尔记法):
C20H30N6Na2O12S2
分子量:
656.59
Beilstein:
6265389
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26

product name

L -氧化谷胱甘肽 二钠盐, ≥98%, powder

品質等級

化驗

≥98%

形狀

powder

技術

HPLC: suitable

雜質

ethanol, essentially free

顏色

white to off-white

儲存溫度

−20°C

SMILES 字串

[Na+].[Na+].N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C([O-])=O)C(=O)NCC(O)=O)C(=O)NCC([O-])=O)C(O)=O

InChI

1S/C20H32N6O12S2.2Na/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38;;/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38);;/q;2*+1/p-2/t9-,10-,11-,12-;;/m0../s1

InChI 密鑰

DRFILBXQKYDTFW-JIWRMXRASA-L

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Amino Acid Sequence

(γ-Glu-Cys-Gly) (γ-Glu-Cys-Gly) [Disulfide bridge: 2a-2b]

應用

L-谷胱甘肽氧化二钠盐已用于5,5′-二硫代双-(2-硝基苯甲酸)(DTNB)/谷胱甘肽还原酶再循环法,以测定血浆或组织的谷胱甘肽水平。它还可用于NADPH依赖性谷胱甘肽二硫化物还原检测。

生化/生理作用

氧化的L-谷胱甘肽常在体内作为测量氧化应激的指示剂。氧化的L-谷胱甘肽可通过各种还原系统转化为L-谷胱甘肽。

相關產品

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Methods for the Determination of Plasma or Tissue Glutathione Levels
Trent E, et.al
Methods in Molecular Biology, 889, 315-324 (2012)
Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver
Sofi Eriksson
Nature Communications (2015)
Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress.
Rossi R
Clinical Chemistry, 52(7), 1406-1414 (2006)
S K Tandon et al.
Toxicology letters, 145(3), 211-217 (2003-10-29)
The influence of an antioxidant agent such as N-acetyl cysteine (NAC) or mannitol on the cadmium chelating ability of monoisoamyl 2,3-dimercaptosuccinate (MiADMS) was investigated in cadmium pre-exposed rats. This ester of 2,3-dimercaptosuccinic acid (DMSA), an accepted drug for lead poisoning
Trent E Tipple et al.
Methods in molecular biology (Clifton, N.J.), 889, 315-324 (2012-06-07)
We present two different methods for determining levels of glutathione in complex biological samples and plasma. The DTNB/GR enzyme recycling method is sensitive and requires no specialized equipment. The HPLC method is particularly useful for situations in which sample amounts

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