生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
存货情况
not available in Japan
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable using human brain, neurons
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GRM7(2917)
mouse ... Grm7(108073)
rat ... Grm7(81672)
一般描述
The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.
免疫原
synthetic peptide corresponding to the N-terminal extracellular domain of human metabotropic glutamate receptor 7, conjugate to KLH. The immunizing peptide has 100% homology with the rat gene and 95% homology with the mouse gene.
应用
Anti-Glutamate Receptor 7, Metabotropic antibody produced in rabbit is suitable for immunohistochemistry using formalin-fixed, paraffin-embedded sections of human brain, neurons.
生化/生理作用
Glutamate Receptor 7 belongs to group III and inhibits adenyl cyclase. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Activation of Group III receptors has been shown to be neuroprotective. Glutamate receptors are important mediators of excitatory amino acid neurotransmission.
外形
Solution in phosphate buffered saline, containing 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
A I Faden et al.
Journal of neurotrauma, 14(12), 885-895 (1998-02-25)
We have used an in vitro trauma model to examine the effects of modulation of group III metabotropic glutamate receptors (mGluR) on post-traumatic neuronal cell death. Rat cortical neuronal/glial cultures were subjected to standardized mechanical injury using a punch that
V Bruno et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(17), 6413-6420 (2000-08-31)
Activation of group III metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, and mGluR8) has been established to be neuroprotective in vitro and in vivo. To disclose the identity of the receptor subtype(s) that exert(s) the protective effect, we have used group
W Spooren et al.
Behavioural pharmacology, 14(4), 257-277 (2003-07-03)
Following the molecular cloning in the early 1990s of the metabotropic glutamate receptors (mGlu1-8), research that focused on the physiology, pharmacology and function of these receptors revealed their potential role in CNS disorders. Numerous psychiatric and neurological dis-orders are indeed
Domenico E Pellegrini-Giampietro
Trends in pharmacological sciences, 24(9), 461-470 (2003-09-12)
Metabotropic glutamate receptors of the mGlu(1) and mGlu(5) subtypes exhibit a high degree of sequence homology and are both coupled to phospholipase C and intracellular Ca(2+) mobilization. However, functional differences have been detected for these receptor subtypes when they are
J P Pin et al.
Neuropharmacology, 34(1), 1-26 (1995-01-01)
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to
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