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F9553

Sigma-Aldrich

FTI-276 trifluoroacetate salt

≥95% (HPLC)

别名:

N-[4-[2-(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt

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About This Item

经验公式（希尔记法）:
C21H27N3O3S2 ·C2HF3O2
CAS号:
170006-72-1
分子量:
547.61
MDL编号:
MFCD06409253
UNSPSC代码:
12352200
PubChem化学物质编号:
329799788
NACRES:
NA.77

质量水平

100

方案

≥95% (HPLC)

表单

film

储存条件

desiccated
under inert gas

颜色

off-white

溶解性

H2O: >5 mg/mL

运输

wet ice

储存温度

−20°C

SMILES字符串

OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2)C(O)=O

InChI

1S/C21H27N3O3S2.C2HF3O2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14;3-2(4,5)1(6)7/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27);(H,6,7)/t15-,19+;/m1./s1

InChI key

IAVHISGQCODLHL-WSCVZUBPSA-N

生化/生理作用

FTI-276 is a highly potent RasCAAX peptidomimetic.
FTI-276 is a highly potent RasCAAX peptidomimetic. FTI-276 antagonizes both H and K-Ras oncogenic signaling. It is an inhibitor of farnesyltransferase (Ftase) in vitro with an IC50 of 500 pM and is an anti-cancer agent.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
035M4609V
090M4636V
029K46171
029K4617
044K4618

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Sphingosine-1-phosphate (S1P) is involved in inflammatory signaling/s associated with the development of respiratory disorders, including cancer. However, the underlying mechanism/s are still elusive. The aim of this study was to investigate the role of S1P on circulating blood cells obtained
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eLife, 10 (2021-02-03)
A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation of HGPS cells and improves survival of Zmpste24-deficient mice. However, we don't know
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