生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
用途
sufficient for 10 blots
种属反应性
human, rat, mouse, Drosophila, frog
技术
western blot: 1:1,000
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... PTK2(5747)
一般描述
Focal adhesion kinase (FAK) is a cytoplasmic protein that belongs to non-receptor protein tyrosine kinase family. It has a critical role in regulation of cell differentiation, migration, adhesion and acceleration of the G1 to S phase transition in cell cycle. Anti-phospho-FAK (pTyr397) antibody can be used in immunocytochemistry and immunohistochemistry. Rabbit anti- phospho-FAK (pTyr397) antibody reacts specifically with FAK (125kD) phosphorylated at tyrosine 397. This product can also react with FAK (pTyr397) of rat, chicken, frog, mouse and human.
免疫原
synthetic phophopeptide derived from the region of FAK that contains tyrosine 397.
应用
Anti-phospho-FAK (pTyr397) antibody can be used in immunoblotting (diluted 1:1000) and microarray.
外形
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
J M Taylor et al.
The Journal of biological chemistry, 275(25), 19250-19257 (2000-04-06)
A variety of agonists including phenylephrine (PE) induce hypertrophy in neonatal ventricular cardiomyocytes. Here we report that signals provided by extracellular matrix proteins (ECM) augment the PE-induced hypertrophic response of cardiomyocytes and provide evidence that ECM-dependent signaling is mediated in
Potential roles for focal adhesion kinase in development.
Ridyard MS, Sanders EJ
Anat. Embryol., 199(1), 1-7 (1999)
Xuelian Tang et al.
Cancer biology & therapy, 5(11), 1474-1480 (2006-10-03)
Herein, we report that marine-derived sulfated polysaccharide (MSP), a new kind of polysaccharide extracted from brown alga, exhibits the anti-migration effect in vitro and potently suppress metastasis of Lewis lung carcinoma in vivo. Adhesion assays demonstrated that MSP inhibits the
Sean E Gill et al.
Developmental biology, 298(2), 540-554 (2006-08-08)
Tissue inhibitors of metalloproteinases (TIMPs) regulate extracellular matrix (ECM) degradation by matrix metalloproteinases (MMPs) throughout embryogenesis. We examined lungs from TIMP3 null mice and found decreased bronchiole branching, enhanced activity of MMPs and enhanced fibronectin degradation throughout lung development compared
J D Owen et al.
Molecular and cellular biology, 19(7), 4806-4818 (1999-06-22)
Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in integrin-mediated control of cell behavior. Following cell adhesion to components of the extracellular matrix, FAK becomes phosphorylated at multiple sites, including tyrosines 397, 576, and 577. Tyr-397 is
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