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形狀
solid
光學活性
[α]25/D 71.0 to 82.0°, c = 1 in dioxane
溶解度
dioxane: 4.0 mL, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)
作用方式
cell membrane | interferes
SMILES 字串
[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COC(=O)C(C)(C)C)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C
InChI
1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1
InChI 密鑰
JWRMHDSINXPDHB-OJAGFMMFSA-N
基因資訊
human ... NR3C1(2908)
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應用
Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is used to study adrenocortical suppression, plasma transcortin binding, and cutaneous atrophy and telangiectasia.
生化／生理作用
Flumethasone pivalate is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activations and repressions. The anti-inflammatory action of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
訊號詞
Warning
危險聲明
危險分類
Carc. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
T Hojyo
The Journal of international medical research, 15(5), 255-263 (1987-09-01)
The combination creams, betamethasone dipropionate/clotrimazole/gentamicin sulphate and flumethasone pivalate/clioquinol, were compared in patients with corticosteroid responsive dermatoses and/or cutaneous fungal and/or bacterial infections. Medication was applied to affected areas twice daily for 28 days. Of 67 patients enrolled, 31 treated
Corticosteroid-Induced Cutaneous Atrophy and Telangiectasia: Experimental Production Associated With Weight Loss in Rats
. Graham Smith, Jr, Richard F. Wehr, et al.
Archives of Dermatological Research, 112, 1115-1117 (1976)
Adrenocortical Suppression With Topical Flumethasone
Richard D. Carr and Ralph G. Wieland
Archives of Dermatological Research, 96, 269-272 (1967)
[Release of flumethasone pivalate from oleogel and W/O emulsion bases in vitro].
W Horsch et al.
Die Pharmazie, 37(11), 807-808 (1982-11-01)
Analysis of flumethasone pivalate formulations by high-performance liquid chromatography.
B A Lodge et al.
Journal of chromatography, 301(2), 477-480 (1984-10-05)
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