E9750

雌素酮

≥99% (HPLC), powder, estrogen receptor agonist

• 别名: 3-羟基雌甾-1,3,5(10)-三烯-17-酮, 雌(三烯酚)酮, 雌酮
• 经验公式（希尔记法）: C₁₈H₂₂O₂
• CAS号: 53-16-7
• 分子量: 270.37
• Beilstein: 1915077
• EC號碼: 200-164-5
• MDL號碼: MFCD00003620
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24278427
• NACRES: NA.77

属性

• product name: 雌素酮, ≥99%
• 生物源: synthetic (organic)
• 無菌: non-sterile
• 化驗: ≥99%
• 形狀: powder
• mp: 258-260 °C (lit.)
• 溶解度: dioxane: 50 mg/mL, clear, colorless to very faintly yellow
• 運輸包裝: ambient
• 儲存溫度: room temp
• SMILES 字串: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
• InChI: 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
• InChI 密鑰: DNXHEGUUPJUMQT-CBZIJGRNSA-N
• 基因資訊: human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , HSD17B1(3292) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Esr1(24890)

说明

一般說明

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

應用

Estrone has been used:

• as medium supplement for hormone based degranulation studies of natural killer cells
• as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
• as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

生化／生理作用

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

特點和優勢

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H351,H360FD,H362
• 防範說明: P202 - P260 - P263 - P264 - P280 - P308 + P313
• 危險分類: Carc. 2 - Lact. - Repr. 1A
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges