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产品名称
大黄素, from Frangula bark, ≥90% (HPLC)
生物源
Frangula bark
品質等級
化驗
≥90% (HPLC)
溶解度
DMSO: soluble
aqueous base: soluble
ethanol: soluble
儲存溫度
2-8°C
SMILES 字串
Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
InChI
1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChI 密鑰
RHMXXJGYXNZAPX-UHFFFAOYSA-N
基因資訊
human ... CSNK2A1(1457) , CSNK2B(1460) , ELA2(1991) , NFKB1(4790) , NKAP(79576) , NKRF(55922)
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一般說明
大黄素是一种从大黄 (Rheum palmatum) 中提取出来的蒽醌衍生物。 它具有抗菌、 抗肿瘤、抗炎和抗血管生成等作用。大黄素具有细胞毒性作用、诱导细胞凋亡并刺激缺氧诱导因子1α、谷胱甘肽 S-转移酶P和 N-乙酰转移酶的表达。 它可以抑制前列腺癌细胞的生长。 大黄素被用于治疗便秘和痔疮。它显示出免疫抑制和抗糖尿病作用。
應用
大黄素已被用于：
- 研究其对脂多糖 (LPS) 诱导的心肌炎炎症损伤的调控机制
- 作为开发和验证高效液相色谱 (HPLC)-光电二极管阵列 (PDA) 检测的参考标准品
- 抑制 Tau 聚集
- 用于直接结合检测
生化／生理作用
抑制 NF-κB 活化和粘附分子表达。酪蛋白激酶 2 (CK2) 抑制剂。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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