生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
fractionated antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~42 kDa by SDS-PAGE
物種活性
human
濃度
~1 mg/mL
技術
western blot: suitable
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... S1PR5(53637)
免疫原
synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-8/S1P5 receptor.
應用
Anti-S1P5, C-Terminal antibody produced in rabbit is suitable for western blotting at a working concentration of 5 to 10 μg/ml using RH7777 cells transfected with full length human EDG-8.
生化／生理作用
Sphingosine-1-phosphate receptor 5 (S1PR5) is a human gene which encodes a G protein-coupled receptor. It binds to lipid signaling molecule sphingosine 1-phosphate (S1P). S1PR5 regulates NK cell migration and distribution by interacting with sphingosine-1-phosphate (S1P). In brain endothelial cells (ECs), it contributes to optimal barrier formation and maintains immune quiescence of the barrier endothelium. S1PR5 is localized in the centrosome of mammalian cells and may participate in regulating mitosis. It may function as an intracellular target of S1P linked to regulation of mitosis.
外觀
Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
Li-Xun Guan et al.
Zhongguo shi yan xue ye xue za zhi, 20(2), 412-415 (2012-05-01)
Natural killer (NK) cells can suppress the development of graft vs host disease (GVHD) while retaining antitumor response in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Sphingosine-1-phosphate receptor 5 (S1PR5) can regulate NK cell migration and distribution in vivo by interacting
Ruben van Doorn et al.
Journal of neuroinflammation, 9, 133-133 (2012-06-22)
The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya®) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has been shown to be related to immunosuppression through the induction of lymphopenia, it
Laura Gillies et al.
Cellular signalling, 21(5), 675-684 (2009-02-13)
We show here that the endogenous sphingosine 1-phosphate 5 receptor (S1P(5), a G protein coupled receptor (GPCR) whose natural ligand is sphingosine 1-phosphate (S1P)) and sphingosine kinases 1 and 2 (SK1 and SK2), which catalyse formation of S1P, are co-localised
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