生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
mouse
技术
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Epha8(13842)
一般描述
The antibody demonstrates ~5% cross-reactivity with recombinant mouse EphA6, EphA7, EphA2, and EphA3 in ELISA and immunoblotting assays. Also, there is approximately 5% cross-reactivity with recombinant human EphA1 and recombinant rat EphA5.
免疫原
purified recombinant mouse EphA8 extracellular domain.
生化/生理作用
EPH receptor A8 is a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. It regulates developmental events, particularly those of the nervous system. EphA8 binds p110γ isoform of PI3-kinase and regulates the integrin-mediated cell adhesion.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
C Gu et al.
Molecular and cellular biology, 21(14), 4579-4597 (2001-06-21)
Recent genetic studies suggest that ephrins may function in a kinase-independent Eph receptor pathway. Here we report that expression of EphA8 in either NIH 3T3 or HEK293 cells enhanced cell adhesion to fibronectin via alpha(5)beta(1)- or beta(3) integrins. Interestingly, a
eph, the largest known family of putative growth factor receptors.
N L Tuzi et al.
British journal of cancer, 69(3), 417-421 (1994-03-01)
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