生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 27 kDa
物種活性
human
包裝
antibody small pack of 25 μg
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1-2 μg/mL using human cerebellum tissue
western blot: 1-3 μg/mL using human SK-N-SH cells
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
基因資訊
human ... HSD17B10(3028)
一般說明
The gene HSD17B10 (hydroxysteroid (17-β) dehydrogenase 10) encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily.
特異性
By immunoblotting, the antibody detects native human ERAB. It does not react with mouse or rat.
免疫原
synthetic peptide corresponding to amino acids 100-116 of human ERAB protein.
應用
Anti-ERAB antibody produced in rabbit is suitable for immunohistochemistry at a working concentration of 1-2μg/mL using human cerebellum tissue with DAB detection and for immunoblotting at 1-3μg/mL using human neuroblastoma SK-N-SH cells with chemiluminescence detection.
生化／生理作用
The gene product is a subunit of mitochondrial ribonuclease P and plays a pivotal role in in mitochondrial tRNA maturation. It catalyzes the oxidation of a wide variety of fatty acids and steroids. The gene is linked to the neuronal dysfunction associated with Alzheimer disease (AD).
外觀
Solution in 0.05 M sodium phosphate buffer, pH 7.5, containing 0.2% gelatin and 0.1% sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
S D Yan et al.
Nature, 389(6652), 689-695 (1997-10-24)
Amyloid-beta is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons
Naeem Shafqat et al.
The Biochemical journal, 376(Pt 1), 49-60 (2003-08-15)
17beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyse the conversion of 17beta-OH (-hydroxy)/17-oxo groups of steroids, and are essential in mammalian hormone physiology. At present, eleven 17beta-HSD isoforms have been defined in mammals, with different tissue-expression and substrate-conversion patterns. We analysed 17beta-HSD type 10
Johann Holzmann et al.
Cell, 135(3), 462-474 (2008-11-06)
tRNAs are synthesized as immature precursors, and on their way to functional maturity, extra nucleotides at their 5' ends are removed by an endonuclease called RNase P. All RNase P enzymes characterized so far are composed of an RNA plus
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