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Merck

D9549

Sigma-Aldrich

[Phe4]-Dermorphin fragment 1-4 amide

≥97% (HPLC)

别名:

TAPP, Tyr-D-Ala-Phe-Phe-NH2

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About This Item

经验公式(希尔记法):
C30H35N5O5
分子量:
545.63
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:

方案

≥97% (HPLC)

储存温度

−20°C

SMILES字符串

CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc2ccccc2)C(=O)NC(Cc3ccccc3)C(N)=O

基因信息

生化/生理作用

Selective μ opiate receptor agonist; lipophilic peptide that appears to cross the blood-brain barrier.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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J Gutkowska et al.
British journal of pharmacology, 119(2), 239-244 (1996-09-01)
1. The effect of i.v. administration of TAPP, a highly selective and exclusively peripherally-acting mu-opioid receptor agonist, on urine output, urinary sodium, potassium and cyclic GMP, and on plasma immunoreactive atrial natriuretic factor (IR-ANF) levels was studied in conscious normally
M Spetea et al.
Peptides, 19(6), 1091-1098 (1998-08-13)
Opioid receptor binding properties of [3H]Tyr-D-Ala-Phe-Phe-NH2 (TAPP) were characterized in rat brain and Chinese hamster ovary (CHO) cells expressing the rat mu-receptor. In rat brain, [3H]TAPP labeled a single class of opioid sites with a dissociation constant (Kd) of 0.31
P W Schiller et al.
Journal of medicinal chemistry, 32(3), 698-703 (1989-03-01)
According to the membrane compartment concept the receptor specificity of ligands is based not only on ligand-receptor complementarity but also on specific ligand-membrane interactions. Elaboration of this concept for opioid peptide-receptor interactions had led to the assumption that mu- and
Sana S Dastgheyb et al.
Clinical orthopaedics and related research, 473(9), 2865-2873 (2015-04-22)
Allograft bone is commonly used to augment bone stock. Unfortunately, allograft is prone to bacterial contamination and current antimicrobial therapies are inadequate. Photoactivated porphyrins combat bacterial growth by production of reactive oxygen species (ROS); however, to our knowledge, they have

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