化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
DMSO: ~18 mg/mL at ~60 °C
儲存溫度
2-8°C
SMILES 字串
OC(=O)c1ccccc1Nc2cc(Cl)cc(Cl)c2
InChI
1S/C13H9Cl2NO2/c14-8-5-9(15)7-10(6-8)16-12-4-2-1-3-11(12)13(17)18/h1-7,16H,(H,17,18)
InChI 密鑰
FNGSQOJHNAYHAT-UHFFFAOYSA-N
基因資訊
human ... TTR(7276)
生化／生理作用
Inhibitor of transthyretin amyloid fibril formation in vitro.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Natàlia Reixach et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(9), 2817-2822 (2004-02-26)
The transthyretin (TTR) amyloidoses are human diseases in which the misfolded TTR protein aggregates in tissues with subsequent visceral, peripheral, and autonomic nerve dysfunction. Recent reports have stressed the importance of oligomeric intermediates as major cytotoxic species in various forms
Per Hammarström et al.
Science (New York, N.Y.), 299(5607), 713-716 (2003-02-01)
Genetic evidence suggests that inhibition of amyloid fibril formation by small molecules should be effective against amyloid diseases. Known amyloid inhibitors appear to function by shifting the aggregation equilibrium away from the amyloid state. Here, we describe a series of
Christopher A Ross et al.
Nature medicine, 10 Suppl, S10-S17 (2004-07-24)
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized to have common cellular and molecular mechanisms including protein aggregation and inclusion body formation. The aggregates
Ellen Y Cotrina et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 26(72), 17462-17469 (2020-08-08)
The protein transthyretin (TTR) modulates amyloid-β (Aβ) peptides deposition and processing and this physiological effect is further enhanced by treatment with iododiflunisal (IDIF), a small-molecule compound (SMC) with TTR tetramer stabilization properties, which behaves as chaperone of the complex. This
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门