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Merck

D7071

Sigma-Aldrich

达泊西汀 盐酸盐

≥98% (HPLC)

别名:

(S)-(+)-N,N-二甲基-1-苯基-3-(1-萘氧基)丙胺盐酸盐, (S)-(+)-N,N-二甲基-a-[2-(萘氧基)乙基]苯甲胺盐酸盐,LY-210448 盐酸盐

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About This Item

经验公式(希尔记法):
C21H23NO · HCl
分子量:
341.87
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D +125 to +135°, c = 1 in methanol

儲存條件

desiccated

顏色

white

溶解度

DMSO: ≥20 mg/mL

起源

Eli Lilly

儲存溫度

room temp

SMILES 字串

Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c3ccccc3

InChI

1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1

InChI 密鑰

IHWDIQRWYNMKFM-BDQAORGHSA-N

基因資訊

human ... SLC6A4(6532)

一般說明

达泊西汀((+)-(S)-N,N-二甲基-(α)-[2(1萘氧基)乙基]-苯甲胺盐酸盐)的结构类似于氟西汀。

生化/生理作用

有效的选择性5-羟色胺再摄取抑制剂(SSRI);用于治疗早泄
达泊西汀可阻断重组Kv4.3电压门控钾通道。已确认为安全的治疗药物。

特點和優勢

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面, 请单击此处
该化合物由Eli Lilly开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Stanley E Althof et al.
The journal of sexual medicine, 7(6), 2243-2252 (2010-04-07)
The Clinical Global Impression of Change (CGIC) measures have high utility in clinical practice. However, it is unknown whether the CGIC is valued for assessing premature ejaculation (PE) symptoms and/or the relationship between CGIC and other validated PE patient-reported measures.
Tae Kon Kim et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 926, 42-46 (2013-04-02)
In this study, we describe and validate a rapid and sensitive method for quantitation of dapoxetine in rat plasma by using ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI/MS/MS). Plasma samples were prepared by protein precipitation with acetonitrile, and sildenafil
Pierre Clément et al.
The journal of sexual medicine, 9(10), 2562-2573 (2012-08-22)
A brain network specifically activated when ejaculation occurs has been described in rats. Increasing serotonin (5-hydroxytryptamine [5-HT]) tone impairs ejaculation and chronic 5-HT selective serotonin reuptake inhibitors (SSRIs) are known to inhibit ejaculation. However, efficacy of acute treatment with SSRI
Dapoxetine: a new option in the medical management of premature ejaculation
McMahon CG
Therapeutic Advances in Urology, 4(5), 233-251 (2012)
Hartmut Porst et al.
The journal of sexual medicine, 7(6), 2231-2242 (2010-04-24)
Premature ejaculation (PE) is classified as an acquired or lifelong condition but data on baseline characteristics and response to treatment of men with acquired or lifelong PE and mild erectile dysfunction (ED) or normal erectile function (EF) is limited. To

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