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About This Item
经验公式（希尔记法）:
C9H13N3O3
CAS号:
分子量:
211.22
Beilstein:
654956
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.52
推荐产品
生物源
synthetic (organic)
化驗
≥98% (HPLC)
形狀
powder
顏色
colorless
mp
217-218 °C (lit.)
溶解度
water: 50 mg/mL, clear, colorless to faintly yellow
儲存溫度
−20°C
SMILES 字串
NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H](CO)O2
InChI
1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1
InChI 密鑰
WREGKURFCTUGRC-POYBYMJQSA-N
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應用
2′,3′-二脱氧胞苷用于:
- 作为基于 Sanger 链终止法的 DNA 测序方法的 DNA 链终止核苷酸
- 作为核苷逆转录酶抑制剂（NRTI）用于研究其对衰老小鼠机械性机械性触诱发痛发展的影响
- 作为线粒体 DNA（mtDNA） 复制抑制剂，用于抑制 cGAS-STING 通路的激活，并研究其对小鼠海马和小胶质细胞中信号蛋白-干扰素基因刺激因子 (STING)、环状 GMP-AMP 合酶 (cGAS) 和磷酸化干扰素调节因子 3 (p-IRF3)表达的影响
- 作为 NRTI 抑制剂用于研究其对秀丽隐杆线虫中药物诱导的线粒体毒性的影响
生化／生理作用
2′,3′-二脱氧胞苷（ddC） 是一种离子化合物和核苷类似物。它可作为核苷类逆转录酶抑制剂，并对人类免疫缺陷病毒（HIV）感染具有治疗作用。2′,3′-二脱氧胞苷具有抗腺病毒活性并抑制腺病毒聚合酶。
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