生物源
mouse
共軛
unconjugated
抗體表格
ascites fluid
無性繁殖
DCS-3, monoclonal
分子量
antigen 33-35 kDa (and several lower and higher MW proteins)
包含
15 mM sodium azide
物種活性
mouse, human
技術
flow cytometry: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:400 using a cultured human tumor cell line extract
同型
IgG2a
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... CCND2(894)
mouse ... Ccnd2(12444)
特異性
The antibody is useful in antibody-mediated knock-out experiments. The product does not cross-react with other D-type cyclins.
免疫原
recombinant human cyclin D2 protein.
J Lukas et al.
Oncogene, 10(11), 2125-2134 (1995-06-01)
To explore regulation and function of cyclin D2, a candidate cell cycle-regulatory proto-oncogene, we examined subcellular localisation, cell type- and cell cycle-dependent expression, and requirement of cyclin D2 protein for G1 progression, in a panel of 40 human normal and
Nathalie M Fiaschi-Taesch et al.
Diabetes, 59(8), 1926-1936 (2010-07-30)
Most knowledge on human beta-cell cycle control derives from immunoblots of whole human islets, mixtures of beta-cells and non-beta-cells. We explored the presence, subcellular localization, and function of five early G1/S phase molecules-cyclins D1-3 and cdk 4 and 6-in the
Kikumi Hata et al.
Journal of immunology (Baltimore, Md. : 1950), 173(4), 2453-2461 (2004-08-06)
The engagement of membrane-bound Igs (mIgs) results in growth arrest, accompanied by apoptosis, in the WEHI-231 murine B lymphoma cells, a cell line model representative of primary immature B cells. Inhibitor of differentiation (Id) proteins, members of the helix-loop-helix protein
Ningli Cheng et al.
PloS one, 3(4), e1911-e1911 (2008-04-03)
The effect of Bcl-2 on oncogenesis is complex and expression may either delay or accelerate oncogenesis. The pro-oncogenic activity is attributed to its well characterized anti-apoptotic function while the anti-oncogenic function has been attributed to its inhibition of cellular proliferation.
Federico Tagliati et al.
Endocrinology, 147(7), 3530-3538 (2006-04-08)
Somatostatin (SRIH) inhibits cell proliferation by interacting with five distinct SRIH receptor subtypes (SSTRs) activating several pathways in many tissues. We previously demonstrated that SRIH, by activating Src homology-2-containing protein, inhibits cell proliferation of the human medullary thyroid carcinoma cell
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