推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
4901, monoclonal
形狀
buffered aqueous solution
物種活性
rat, human, canine
包裝
antibody small pack of 25 μL
濃度
~2 mg/mL
技術
immunocytochemistry: suitable
indirect ELISA: 0.5 μg/mL using rat α-CGRP
neutralization: suitable
radioimmunoassay: suitable
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CALCA(796)
rat ... Calca(24241)
一般說明
CGRP(降钙素基因相关肽)属于降钙素家族,主要在中枢和周围神经系统中表达。它是一种强效血管舒张剂。偏头痛发作时CGRP 浓度增加, 因此,它参与偏头痛的发病机理。单克隆抗-降钙素基因相关肽抗体可用于免疫中和和放射免疫测定。小鼠抗降钙素基因相关肽抗体与大鼠α-CGRP的C末端10个氨基酸中的抗原表位发生特异性反应,并且与人和狗的α和β-CGRP发生交叉反应。
降钙素基因相关肽(CGRP)是一种血管舒张剂,属于降钙素肽家族。它由周围和中枢神经紧张系统的运动神经元产生。CGRP有两种形式,α和β,它们具有相似的功能。CGRP的作用是由降钙素受体样受体(CRLR)和受体活性修饰蛋白1(RAMP1)形成的G蛋白偶联受体异二聚体介导的。 CGRP在神经紧张、内分泌、免疫和心血管系统中具有多种生物学作用。 多项研究表明CGRP与偏头痛的病理生理有关,研究人员正在探索将CGRP的拮抗剂作为治疗方案。
单克隆抗降钙素基因相关肽(CGRP)可识别大鼠α-CGRP。该抗体可与人和狗的α-和β-CGRP发生交叉反应。
单克隆抗降钙素基因相关肽(CGRP)可识别大鼠α-CGRP。该抗体可与人和狗的α-和β-CGRP发生交叉反应。
免疫原
大鼠α-CGRP肽。抗体识别的表位位于大鼠α-CGRP的C端十个氨基酸内。
應用
单克隆抗降钙素基因相关肽抗体可用于免疫细胞化学和免疫组化。它也可以用于ELISA中。
抗降钙素基因相关肽(CGRP)抗体适用于ELISA ,工作浓度为0.25- 0.5 μg/ml。该抗体可以在大鼠神经纤维和人背根神经节中以1:100的工作稀释度用于免疫荧光。
外觀
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
其他客户在看
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