C6617

CBIQ

≥98% (HPLC), solid

• 别名: 4-Chlorobenzo[f]isoquinoline
• 经验公式（希尔记法）: C₁₃H₈NCl
• CAS号: 32081-28-0
• 分子量: 213.66
• MDL號碼: MFCD02179769
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724450
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 顏色: off-white
• 溶解度: DMSO: 15 mg/mL
• SMILES 字串: Clc1nccc2c1ccc3ccccc23
• InChI: 1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
• InChI 密鑰: SHQLTRRYZVBEMR-UHFFFAOYSA-N

说明

生化／生理作用

CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

特點和優勢

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS06,GHS05
• 訊號詞: Danger
• 危險聲明: H301,H315,H318,H335
• 防範說明: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• 危險分類: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges