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生物源
mouse
共軛
unconjugated
抗體表格
ascites fluid
抗體產品種類
primary antibodies
無性繁殖
CXN-32, monoclonal
形狀
buffered aqueous solution
分子量
antigen 27 kDa
包含
15 mM sodium azide
物種活性
human, rat, mouse
技術
immunohistochemistry (frozen sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:1,000 using a mouse whole brain extract
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... GJB1(2705) , GJB2(2706)
mouse ... Gjb1(14618)
rat ... Gja1(24392) , Gjb1(29584)
一般說明
Monoclonal Anti-Connexin-32 (mouse IgG1 isotype) is derived from the CXN-32 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The 27 kDa connexin protein (Connexin-32, Cx32), belongs to the connexion family of proteins. It is expressed in most tissues, even though the pattern of expression may differ in various cell types including peripheral and central nervous system.
免疫原
synthetic connexin-32 peptide (amino acids 105-123).
應用
Monoclonal Anti-Connexin-32 antibody produced in mouse has been used in:
- enzyme linked immunosorbent assay (ELISA)
- immunoblotting
- epifuorescent microscopy
生化／生理作用
Connexin-32 low expression levels is observed in common bile duct ligation (CBDL). In addition, a combination of myelin disruption and axonal degeneration has been shown to occur with Cx32 mutations in Charcot-Marie-Tooth disease (CMTX). Monoclonal antibodies reacting specifically with Cx32, may be used in diverse cellular and molecular approaches to the study of gap junctions and their properties, and to correlate their expression pattern with physiological functions or pathological conditions.
Connexins belong to the gap junction protein family. In humans, connexin is encoded by GJB1 (gap junction protein, β 1) gene. The gap junction proteins connexin32 (Cx32), Cx37, Cx40 and Cx43 are expressed in endothelial cells and regulate vascular functions involving inflammation. The endothelial Cx32 positively regulates angiogenesis by enhancing endothelial cell tube formation and cell migration. CX32 mutation is associated with cognitive impairment and a differential degree of peripheral nerve involvement.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Connexins modulate autophagosome biogenesis
Bejarano E, et al.
Nature Cell Biology, 16(5), 401-401 (2014)
Three-dimensional binding of epidermal growth factor peptides in colonic tissues produced from rotating bioreactor
Kaeffer B, et al.
In Vitro Cellular & Developmental Biology. Animal, 38(8), 436-439 (2002)
What?s the function of connexin 32 in the peripheral nervous system?
Bortolozzi M
Frontiers in Molecular Neuroscience, 11 (2018)
Structural studies of N-terminal mutants of Connexin 26 and Connexin 32 using (1)H NMR spectroscopy.
Yuksel Batir et al.
Archives of biochemistry and biophysics, 608, 8-19 (2016-07-06)
Alterations in gap junctions underlie the etiologies of syndromic deafness (KID) and Charcot-Marie Tooth disease (CMTX). Functional gap junctions are composed of connexin molecules with N-termini containing a flexible turn around G12, inserting the N-termini into the channel pore allowing
Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver
Kojima T, et al.
Cell communication & adhesion, 10(4-6), 437-443 (2003)
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