生物源
goat
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
mouse
技術
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt登錄號
儲存溫度
−20°C
基因資訊
mouse ... Tnfsf8(21949)
一般說明
CD30 Ligand (CD30L) is a type II membrane glycoprotein of the tumor necrosis factor (TNF) superfamily. It is expressed on the cell surface of activated T cells, B cells, and monocytes. CD30L is also present in other cells, including mature dendritic cells, macrophages and mast cells. CD30L is also reffered to as Tnfsf8 (Tumor necrosis factor ligand superfamily member 8).
免疫原
purified recombinant mouse CD30 ligand (amino acids 68-239) extracellular domain, expressed in NSO cells.
應用
Anti-CD30 antibody produced in goat is suitable for indirect ELISA at a concentration of 0.5-1.0μg/mL and western blotting at a concentration of 0.1-0.2μg/mL.
生化／生理作用
CD30L (CD30 ligand) along with CD30 is involved in activation and proliferation of T and B cells. They are also involved in the regulation of initial artherosclerosis development. CD30L/CD30 is crucial for maintenance and activation of IL (Interleukin)-17A-producing γδ T cells. CD30L/CD30 causes down-regulation of IL-2, resulting in Th17 differentiation of CD4+ T cells. CD30L helps in memory phenotype CD4+ T cells-mediated protection against infection with Listeria monocytogenes. CD30L/CD30 signaling is critical for Th1 response against Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection. They are also linked to allergic rhinitis pathogenesis in mice. CD30L/CD30 signaling is involved in pathogenesis of inflammatory bowel diseases.
外觀
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
X Sun et al.
Mucosal immunology, 6(6), 1191-1201 (2013-04-04)
CD30 ligand (CD30L, CD153), a member of the tumor necrosis factor (TNF) superfamily, and its receptor CD30 are important for differentiation and activation of CD4(+) T helper type 17 (Th17) cells. In this report, we demonstrate that the interleukin 17A
H J Gruss et al.
The American journal of pathology, 149(2), 469-481 (1996-08-01)
The CD30 ligand (CD30L) is a type II transmembrane glycoprotein of the tumor necrosis factor ligand superfamily. Recent cloning of CD30L has enabled studies to explore its function and tissue distribution. For instance, recombinant CD30L has been shown to co-stimulate
Amanda C Foks et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(12), 2862-2868 (2012-10-23)
Costimulatory molecules tightly control immune responses by providing positive signals that promote T-cell activation or by transducing inhibitory signals that limit T-cell responses. CD30 and CD30L are members of the tumor necrosis factor receptor superfamily and are involved in the
Xun Sun et al.
Gastroenterology, 134(2), 447-458 (2008-02-05)
A CD30-ligand (CD30L) is a 40-kilodalton, type II membrane-associated glycoprotein belonging to the tumor necrosis factor family. Serum levels of soluble CD30 increased in inflammatory bowel diseases (IBD), suggesting that CD30L/CD30 signaling is involved in the pathogenesis of IBD. In
Kenji Umeda et al.
Microbiology and immunology, 55(9), 645-656 (2011-06-28)
CD30 ligand (CD30L, CD153) is a type II membrane-associated glycoprotein belonging to the tumor necrosis factor family. It is shown here that CD30L knock out (KO) mice are highly susceptible to primary infection with Listeria monocytogenes as assessed by the
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