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方案
≥98% (HPLC)
表单
solid
颜色
white
mp
221-222.3 °C
溶解性
DMSO: 17 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Cl[H].CCOC(=O)COc1ccc2C(C)=C(CCN(CC)CC)C(=O)Oc2c1Cl
InChI
1S/C20H26ClNO5.ClH/c1-5-22(6-2)11-10-15-13(4)14-8-9-16(26-12-17(23)25-7-3)18(21)19(14)27-20(15)24;/h8-9H,5-7,10-12H2,1-4H3;1H
InChI key
CCCZJRFQJNGCCU-UHFFFAOYSA-N
生化/生理作用
Antithrombotic coumarin derivative that inhibits platelet and leukocyte function and suppresses arachidonic acid liberation by interfering with PLA2 activation.
Carmelo Muià et al.
Naunyn-Schmiedeberg's archives of pharmacology, 373(1), 51-59 (2006-03-31)
Recent studies have demonstrated that cloricromene, a coumarin derivative, exerts protective effects in models of inflammation and shock. Tumour necrosis factor plays a pivotal role in the induction of genes involved in physiological processes, as well as in the response
Rosario Pignatello et al.
AAPS PharmSciTech, 7(1), E27-E27 (2006-04-06)
The purpose of this study was to improve the stability of cloricromene (AD6) in ophthalmic formulations and its drug availability at the ocular level. To this end, AD6-loaded polymeric nanoparticle suspensions were made using inert polymer resins (Eudragit RS100 and
Ornella Francioso et al.
Langmuir : the ACS journal of surfaces and colloids, 35(13), 4518-4526 (2019-02-15)
The adsorption of humic substances on Ag nanoparticles (AgNPs) is of crucial environmental importance and determines the toxicity of these NPs and the structure of adsorbed organic matter. In this work, the adsorption of two standard soil and leonardite International Humic
A Ianaro et al.
Naunyn-Schmiedeberg's archives of pharmacology, 370(2), 140-145 (2004-08-24)
In this study we investigated, for the first time in vivo, the effect of cloricromene, a cumarine derivative, on NF-kappaB activation in endotoxin-treated rats. Endotoxemia was induced in male rats by the intravenous injection of Salmonella typhosa lipopolysaccharide (LPS; 2
E Ribaldi et al.
British journal of pharmacology, 118(6), 1351-1358 (1996-07-01)
1. A phospholipase A2 (PLA2) represents the key enzyme in the remodelling pathway of platelet-activating factor (PAF) synthesis in human polymorphonuclear (PMN) leucocytes. 2. PLA2 activation is also the rate-limiting step for the release of the arachidonic acid utilized for
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