化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
room temp
SMILES 字串
CC1=CC(N2CCOCC2)=CC3=C1NC(C4=C(NC[C@@H](O)C5=CC(Cl)=CC=C5)C=CNC4=O)=N3
生化／生理作用
BMS-536924 is a potent, orally active, ATP-competitive insulin-like growth gactor-1 receptor (IGF1R) inhibitor that shows anticancer activities in preclinical models.
特點和優勢
BMS-536924 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.
法律資訊
Sold for research purposes only under agreement from BMS.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Beate C Litzenburger et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(1), 226-237 (2009-01-02)
This study aimed to test the ability of a new insulin-like growth factor receptor (IGF-IR) tyrosine kinase inhibitor, BMS-536924, to reverse the ability of constitutively active IGF-IR (CD8-IGF-IR) to transform MCF10A cells, and to examine the effect of the inhibitor
Jenny C Potratz et al.
Cancer research, 70(21), 8770-8781 (2010-10-21)
The insulin-like growth factor-1 receptor (IGF1R) is emerging as a promising therapeutic target in human cancers. In the high-risk childhood sarcomas Ewing family tumor and rhabdomyosarcoma, IGF1R-blocking antibodies show impressive antitumor activity in some but not all patients, and acquired
Carly Jade Dool et al.
Endocrine-related cancer, 18(6), 699-709 (2011-09-29)
Epidemiologic and experimental evidence suggest that a subset of breast cancer is insulin responsive, but it is unclear whether safe and effective therapies that target the insulin receptor (IR), which is homologous to oncogenes of the tyrosine kinase class, can
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