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Merck

B6029

Sigma-Aldrich

Nα-Adamantaneacetyl-D-Arg-[Hyp3, Thi5,8, D-Phe7]-Bradykinin

≥97% (HPLC)

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About This Item

经验公式(希尔记法):
C68H99N19O14S2
分子量:
1470.76
MDL编号:
UNSPSC代码:
12352200

方案

≥97% (HPLC)

储存温度

−20°C

SMILES字符串

NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]4C[C@@H](O)CN4C(=O)[C@@H]5CCCN5C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)CC67CC8CC(CC(C8)C6)C7)C(O)=O

基因信息

human ... BDKRB2(624)
mouse ... BDKRB2(12062)
rat ... BDKRB2(25245)

Amino Acid Sequence

Nα-Adamantaneacetyl-D-Arg-Arg-Pro-Hydroxy-Pro-Gly-β-(2-Thienyl)Ala-Ser-D-Phe-β-(2-Thienyl)Ala-Arg

生化/生理作用

A highly potent antagonist at bradykinin B2 receptors with no agonist activity.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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B Lammek et al.
Peptides, 11(5), 1041-1043 (1990-09-01)
We report that the acylation of the N-terminus of [D-Arg0,Hyp3,Thi5,8,D-Phe7]bradykinin, one of the most potent bradykinin antagonists described to date, with 1-adamantane-acetic acid, results in an analogue with more than ten times enhanced potency. The new analogue does not increase
J A García-Sáinz et al.
Biochemistry and molecular biology international, 47(6), 927-933 (1999-07-20)
In C9 rat liver cells bradykinin and kallidin increased (approximately 2-fold) the intracellular concentration of calcium, but the B1 agonist, des-Arg9-bradykinin did not. The effect of bradykinin was inhibited by the B2 antagonists, Hoe 140 and N-alpha-adamantaneacetyl-D-Arg-[Hyp3, Thi5,8, D-Phe7]-bradykinin, but
Man Zhang et al.
American journal of physiology. Cell physiology, 296(6), C1364-C1372 (2009-04-03)
Bradykinin (BK) is an endogenous peptide with diverse biological actions and is considered to be an important mediator of the inflammatory response in both the peripheral and the central nervous systems. BK has attracted recent interest as a potential mediator

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