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方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
yellow
溶解性
DMSO: >20 mg/mL
储存温度
2-8°C
SMILES字符串
Cn1cccc1\C=C2/C(=O)NC(=O)c3ccccc23
InChI
1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9-
InChI key
BTYSIDSTHDDAJW-LCYFTJDESA-N
基因信息
human ... PARP1(142)
mouse ... PARP1(11545)
rat ... PARP1(25591)
生化/生理作用
BYK204165 is a potent and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1). It is 100-fold selective for PARP-1 over PARP-2.
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ningbo Zheng et al.
Cancer cell, 40(9), 973-985 (2022-08-27)
Cytotoxicity of tumor-specific T cells requires tumor cell-to-T cell contact-dependent induction of classic tumor cell apoptosis and pyroptosis. However, this may not trigger sufficient primary responses of solid tumors to adoptive cell therapy or prevent tumor antigen escape-mediated acquired resistance. Here
Robin M Hallett et al.
Molecular oncology, 10(9), 1461-1472 (2016-09-08)
In the pediatric cancer neuroblastoma (NB), patients are stratified into low, intermediate or high-risk subsets based in part on MYCN amplification status. While MYCN amplification in general predicts unfavorable outcome, no clinical or genomic factors have been identified that predict
Facundo H Prado Spalm et al.
Molecular neurobiology, 56(7), 4760-4777 (2018-11-06)
Ceramide (Cer) has a key role inducing cell death and has been proposed as a messenger in photoreceptor cell death in the retina. Here, we explored the pathways induced by C2-acetylsphingosine (C2-Cer), a cell-permeable Cer, to elicit photoreceptor death. Treating
Erika A Newman et al.
Molecular cancer research : MCR, 13(3), 470-482 (2015-01-08)
In neuroblastoma, MYCN genomic amplification and segmental chromosomal alterations including 1p or 11q loss of heterozygocity and/or 17q gain are associated with progression and poor clinical outcome. Segmental alterations are the strongest predictor of relapse and result from unbalanced translocations
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