推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
43 kDa
物種活性
human, dog, bovine
濃度
0.5 mg - 1 mg/mL
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NDRG1(10397)
一般說明
N-myc downstream regulated 1 (NDRG1) is a cytoplasmic hydrolase that modulates stress, hormonal responses, cell growth, differentiation and LDL receptor trafficking. It mediates antimetastatic effects in cancer cells and is downregulated in prostate cancer cells.
Rabbit Anti-NDRG1 antibody recognizes canine, chicken, mouse, zebrafish, bovine, human, and rat NDRG1.
Rabbit Anti-NDRG1 antibody recognizes canine, chicken, mouse, zebrafish, bovine, human, and rat NDRG1.
免疫原
Synthetic peptide directed towards the C terminal region of human NDRG1
應用
Rabbit Anti-NDRG1 antibody is suitable for western blot applications at a concentration of western blot applications at a concentration of 2.5 μg/ml.
生化／生理作用
NDRG1 is a member of the N-myc downregulated protein family which belongs to the alpha/beta hydrolase superfamily. NDRG1 is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in its gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom.This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom.
序列
Synthetic peptide located within the following region: GSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGA
外觀
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Ranlu Liu et al.
PloS one, 8(7), e68982-e68982 (2013-07-23)
MicroRNAs, non-coding 20-22 nucleotide single-stranded RNAs, result in translational repression or degradation and gene silencing of their target genes, and significantly contribute to the regulation of gene expression. In the current study, we report that miR-182 expression was significantly upregulated
Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.
Jing Sun et al.
Carcinogenesis, 34(9), 1943-1954 (2013-05-15)
The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, being a promising new target for cancer treatment. However, the precise molecular effects of NDRG1 remain unclear. Herein, we summarize recent advances
Vilja Pietiäinen et al.
Journal of cell science, 126(Pt 17), 3961-3971 (2013-07-03)
N-myc downstream-regulated gene 1 (NDRG1) mutations cause Charcot-Marie-Tooth disease type 4D (CMT4D). However, the cellular function of NDRG1 and how it causes CMT4D are poorly understood. We report that NDRG1 silencing in epithelial cells results in decreased uptake of low-density
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