生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
分子量
32 kDa
种属反应性
canine, rat, human, rabbit, horse, mouse, pig, bovine
浓度
0.5 mg - 1 mg/mL
技术
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
储存温度
−20°C
基因信息
human ... SFRS10(6434)
一般描述
Transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (TRA2B, SFRS10) is an alternative splicing regulator that itself exists as alternative splice variants. Alternative mRNA splicing provides transcript diversity. SFRS10 binds SMN1/SMN2 RNA and restores full-length (FL)-SMN2 mRNA levels in vitro. Deficiency of SFRS10 results in early embryonic lethality.
特异性
Anti-SFRS10 (AB1) polyclonal antibody reacts with canine, chicken, human, mouse, rat, pig, and bovine transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) proteins.
免疫原
The immunogen for anti-SFRS10 antibody: synthetic peptide derected towards the N terminal of human SFRS10
应用
Anti-SFRS10 (AB1) polyclonal antibody is used to tag transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) in the regulation of alternative pre-mRNA splicing.
序列
Synthetic peptide located within the following region: MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKS
外形
Lyophilized from PBS buffer with 2% sucrose
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Somsakul Pop Wongpalee et al.
eLife, 5 (2016-11-25)
Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found that PTBP1 binding
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Devi Krishna Priya Karunakaran et al.
Gene expression patterns : GEP, 13(8), 425-436 (2013-08-13)
Processing of mRNAs including, alternative splicing (AS), mRNA transport and translation regulation are crucial to eukaryotic gene expression. For example, >90% of the genes in the human genome are known to undergo alternative splicing thereby expanding the proteome production capacity
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