重組細胞
expressed in E. coli
化驗
>80% (SDS-PAGE)
形狀
buffered aqueous solution
分子量
predicted mol wt 33 kDa
純化經由
immobilized metal affinity chromatography (IMAC)
濃度
≥0.5 mg/mL
免疫原序列
KCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEK
Ensembl | 人類登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... XRCC4(7518)
一般說明
Recombinant protein fragment of Human XRCC4 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. X-ray repair cross-complementing protein 4 (XRCC4) is also known as DNA repair protein XRCC4. It is mapped to human chromosome locus 5q14.2. It mediates joining of DNA double strand breaks during DNA repair.
應用
Suitable as a blocking agent using corresponding antibodies.
生化／生理作用
X-ray repair cross-complementing protein 4 (XRCC4) interacts with XRCC4-like factor (XLF) and DNA ligase IV in mediating nonhomologous end joining (NHEJ) cascade in DNA repair. A mutation in the XRCC4 is associated with adult-onset progressive encephalocardiomyopathy and ataxia. Patients with polymorphisms in XRCC4 gene are susceptible to schizophrenia. Single nucleotide polymorphisms in XRCC4 associates with high risk for cancer development. Mutations in XRCC4 leads to growth failure resulting in short stature accompanied by facial dysmorphism.(10)
聯結
Corresponding Antibody HPA006801.
外觀
Solution in 1 M urea-PBS, pH 7.4
準備報告
The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
法律資訊
Prestige Antigens is a trademark of Sigma-Aldrich Co. LLC
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA
Brouwer I, et al.
Nature, 535(7613), 566-566 (2016)
Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability
Rosin N, et al.
Human Molecular Genetics, 24(13), 3708-3717 (2015)
An updated meta-analysis of XRCC4 polymorphisms and cancer risk based on 31 case-control studies
Shao N, et al.
Cancer Biomarkers : Section A of Disease Markers, 12(1), 37-47 (2013)
A nonsense mutation of human XRCC4 is associated with adult-onset progressive encephalocardiomyopathy
Bee L, et al.
EMBO Molecular Medicine, 7(7), 918-929 (2015)
XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency
Guo C, et al.
The Journal of Allergy and Clinical Immunology, 136(4), 1007-1017 (2015)
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