化驗
>98% (HPLC)
形狀
solid
顏色
off-white
溶解度
DMSO: soluble 24 mg/mL
H2O: insoluble
SMILES 字串
CCS(=O)(=O)Nc1cccc(c1)C(=C2/CCCCC2)\c3cnc[nH]3
InChI
1S/C18H23N3O2S/c1-2-24(22,23)21-16-10-6-9-15(11-16)18(17-12-19-13-20-17)14-7-4-3-5-8-14/h6,9-13,21H,2-5,7-8H2,1H3,(H,19,20)
InChI 密鑰
MTZVJHSZYMWIAG-UHFFFAOYSA-N
基因資訊
human ... ADRA1D(146)
應用
A-315456 is a potent and selective α1D-antagonist that may serve as a useful pharmacological ligand to probe the physiological role of the α(1D)-adrenoceptor subtype in normal and disease states.
生化/生理作用
Selective α1D-adrenoceptor antagonist.
特點和優勢
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
European journal of pharmacology, 433(1), 123-127 (2002-01-05)
In functional assays, A-315456, N-[3-(cyclohexylidene-(1H-imidazol-4-ylmethyl))phenyl]ethanesulfonamide, behaved as an alpha(1D)-adrenoceptor subtype selective antagonist (pA(2)=8.34) in the rat aorta. It was 83-fold less potent at the alpha(1B)-adrenoceptor subtype expressed in the rat spleen, and was inactive at the alpha(1A)-adrenoceptor subtype expressed in
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