方案
≥98% (TLC)
储存温度
−20°C
SMILES字符串
OC[C@H]1O[C@H](C[C@H]1N=[N+]=[N-])N2C=CC(=O)NC2=O
应用
3′-Azido-2′,3′-dideoxyuridine has shown potent anti-HIV activity in vitro.
生化/生理作用
Inhibitor of HIV replication.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Z Zhu et al.
Molecular pharmacology, 38(6), 929-938 (1990-12-01)
3'-Azido-2',3'-dideoxyuridine (AzdU, CS-87) is a potent inhibitor of human immunodeficiency virus replication in human peripheral blood mononuclear cells (PBMC) with limited toxicity for human bone marrow cells (BMC). In the present study, metabolism of AzdU was investigated in human PBMC
Linghui Kong et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 795(2), 371-376 (2003-10-03)
3'-Azido-2',3'-dideoxyuridine (AZDU) is a nucleoside analog structurally similar to zidovudine (AZT) with proven activity against human immunodeficiency virus (HIV). The purpose of this study was to develop and validate a high-performance liquid chromatographic (HPLC) method to quantitatively determine AZDU and
K K Manouilov et al.
Drug metabolism and disposition: the biological fate of chemicals, 23(6), 655-658 (1995-06-01)
Recently, it was shown that human immunodeficiency virus (HIV)-infected cells preferentially locate in lymphoid tissue early in the course of infection. Therefore, it is important to characterize the disposition of the anti-HIV agents, 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2', 3'-dideoxyuridine (AZdU), in
A Resetar et al.
Biochemical pharmacology, 42(3), 559-568 (1991-07-15)
The enzymatic glucuronidation of 3'-azido-3'-deoxythymidine (AZT) catalyzed by human liver microsomal UDP-glucuronosyltransferase (EC 2.4.1.17, UDPGT) was inhibited by a number of nucleoside analogs. The inhibitory potency of these nucleoside analogs correlated with their hydrophobicity (r2 = 0.90, N = 13).
K J Doshi et al.
Drug metabolism and disposition: the biological fate of chemicals, 17(6), 590-594 (1989-11-01)
The pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU, CS-87), active anti-HIV compounds, were characterized in uninfected mice. Sensitive and specific HPLC techniques were used to quantitate AZT and AZddU concentrations in serum and brain homogenates following iv doses of 50
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