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Merck
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文件

A0779

Sigma-Aldrich

p-氨基可乐亭 盐酸盐

solid

别名:

2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride, Apraclonidine hydrochloride

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About This Item

经验公式（希尔记法）:
C9H10Cl2N4 · xHCl
分子量:
245.11 (free base basis)
MDL號碼:
MFCD00135922
分類程式碼代碼:
12352200
PubChem物質ID:
24277751
NACRES:
NA.77

形狀

solid

顏色

white

溶解度

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL (Solutions may be stored for several days at 4 °C)
boiling water: 100 mg/mL (Solutions may be stored for several days at 4 °C)
0.1 M HCl: soluble (Solutions may be stored for several days at 4 °C)
methanol: soluble (Solutions may be stored for several days at 4 °C)

儲存溫度

2-8°C

SMILES 字串

Cl[H].Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1

InChI

1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2,12H2,(H2,13,14,15);1H

InChI 密鑰

OTQYGBJVDRBCHC-UHFFFAOYSA-N

基因資訊

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

生化／生理作用

α2-adrenoceptor agonist.

特點和優勢

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301 + H311 + H331

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析证书(COA)

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J Cepelík et al.
Physiological research, 46(3), 203-208 (1997-01-01)
The effects of the selective alpha2-adrenergic agonist p-aminoclonidine, the nonselective adrenergic agonist epinephrine, the selective beta2-adrenergic agonist fenoterol and the adenosine A1 agonist R-PIA on intraocular pressure were studied in control and pertussis toxin-pretreated rabbits. Pretreatment of rabbits with pertussis
T Salminen et al.
The Journal of biological chemistry, 274(33), 23405-23413 (1999-08-07)
We have compared bacteriorhodopsin-based (alpha(2A)-AR(BR)) and rhodopsin-based (alpha(2A)-AR(R)) models of the human alpha(2A)-adrenengic receptor (alpha(2A)-AR) using both docking simulations and experimental receptor alkylation studies with chloroethylclonidine and 2-aminoethyl methanethiosulfonate hydrobromide. The results indicate that the alpha(2A)-AR(R) model provides a better
M E Alburges et al.
Brain research bulletin, 32(2), 97-102 (1993-01-01)
The localization of alpha 2-receptors was determined by quantitative autoradiography using [125I]para-iodoclonidine ([125I]PIC) and [3H]para-aminoclonidine ([3H]PAC). In cortical tissue, [125I]PIC and [3H]PAC were equipotent in their capacity to bind sites recognized by oxymetazoline (preferentially binds to the alpha 2A receptor

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α2-Adrenoceptors

Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.

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