所有图片(1)

文件

A0355

AC-7954

Name: AC-7954
Brand: SIGMA

≥98% (HPLC), solid

别名:

(±)-3-(4-Chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one hydrochloride

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₉H₂₀ClNO₂ · HCl

CAS号:

477313-09-0

分子量:

366.28

MDL號碼:

MFCD07784497

分類程式碼代碼:

12352202

PubChem物質ID:

24724382

NACRES:

NA.77

化驗

≥98% (HPLC)

形狀

solid

顏色

white

溶解度

H₂O: ~28 mg/mL

SMILES 字串

Cl.CN(C)CCC1(Cc2ccccc2C(=O)O1)c3ccc(Cl)cc3

InChI

1S/C19H20ClNO2.ClH/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19;/h3-10H,11-13H2,1-2H3;1H

InChI 密鑰

AJPGLOWFIBOGMH-UHFFFAOYSA-N

基因資訊

human ... UTS2R(2837)

生化／生理作用

Nonpeptide GPR14 / urotensin-UII (UII) receptor agonist that has an EC₅₀ of 300 nM at the human UII receptor (h-UTR). AC-7954 has been shown to exist in two conformations, A and B; both conformations have a pharmacophoric distance within 0.5 Å of P5U, a potent peptidic UII agonist.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954).

Glenn E Croston et al.

Journal of medicinal chemistry, 45(23), 4950-4953 (2002-11-01)

A functional cell-based screen identified 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one hydrochloride (AC-7954, 1) as a nonpeptidic agonist of the urotensin-II receptor. Racemic 1 had an EC50 of 300 nM at the human UII receptor and was highly selective. Testing of the enantiopure (+)- and

Unraveling the active conformation of urotensin II.

Alfonso Carotenuto et al.

Journal of medicinal chemistry, 47(7), 1652-1661 (2004-03-19)

Urotensin II (U-II) is a disulfide-bridged undecapeptide recently identified as the ligand of an orphan G-protein-coupled receptor. Human U-II (H-Glu-Thr-Pro-Asp-cyclo[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH) has been described as the most potent vasoconstrictor compound identified to date. With the aim of elucidating the active conformation

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

文件