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About This Item
经验公式（希尔记法）:
C17H13ClNO5P
CAS号:
分子量:
377.72
Beilstein:
6664478
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.83
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化驗
≥80% (HPLC)
形狀
powder
應用
histology
儲存溫度
2-8°C
SMILES 字串
OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
InChI
1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
InChI 密鑰
RQAQWBFHPMSXKR-UHFFFAOYSA-N
相关类别
應用
Naphthol AS-E磷酸盐已被用作cAMP反应元件结合蛋白（CREB）的抑制剂，以溶解于二甲基亚砜（DMSO）中作为研究中的储存溶液，来验证制癌蛋白M（OSM）可能会赋予针对3-硝基丙酸（3-NP）的神经元抗性的假设。
生化／生理作用
Naphthol AS-E磷酸盐/KG501是一种小分子拮抗剂，具有阻止cAMP反应元件结合蛋白（CREB）通路的能力。它还可在体外干扰Myb-KIX的相互作用并阻断Myb在体内的作用。
其他說明
碱性磷酸酶的组织化学底物，KG-501可通过干扰CREB的KID结构域和CBP（CREB结合蛋白）的KIX结构域之间这一经典的激活剂-共激活因子互作结合，来阻断CREB（cAMP反应元件结合蛋白）依赖性靶基因转录（Ki 10 microM）的cAMP-诱导。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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