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Merck

53471

Sigma-Aldrich

FITC-CM-葡聚糖

average mol wt 70,000

别名:

FITC-CM-葡聚糖 70, 异硫氰酸荧光素-羧甲基-右旋糖酐

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About This Item

分類程式碼代碼:
12352116
NACRES:
NA.32

共軛

FITC conjugate

形狀

powder or crystals

分子量

average mol wt 70,000

成份

carboxymethyl content, 3-7%

標籤範圍

0.001-0.020 mol/mol FITC glucose

技術

permeability assay: suitable

螢光

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

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一般說明

FITC-CM-葡聚糖,也称异硫氰酸荧光素–羧甲基–葡聚糖,是一种阴离子荧光探针。羧基提供了负电荷,其改善分子的总体渗透性。它是以黄色粉末形式供货,易溶于水和电解质溶液。FITC-CM-葡聚糖不溶于大多数有机样品,如乙醇、甲醇、丙酮和氯仿。FITC-CM-葡聚糖是通过选定的葡聚糖与活化的羧甲基衍生物在碱中反应制造,通过反应O-甲氧基被引入葡聚糖链。

應用

FITC-CM-葡聚糖用于研究HeLa 细胞系中的药物摄入和输送机制。选择FITC-CM-葡聚糖是因为其水溶性高并带负电。它也是胶囊化研究的合适分子,可用于聚合物囊泡药物递送体系(或称Ps DDS)。选择FITC-CM-葡聚糖是一种生物相容性分子,可用作多种制药和诊断应用中的起始原料。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Chloe Martin et al.
International journal of pharmaceutics, 511(1), 570-578 (2016-07-28)
The need to develop a greater understanding of drug delivery systems has arisen through the development of alternative biological based therapeutics. Drug delivery systems need to adapt and respond to this increasing demand for cellular transportation of highly charged species.
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)
Yogy Simanjuntak et al.
PLoS pathogens, 16(5), e1008521-e1008521 (2020-05-12)
Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregnancy, folic acid (FA) supplementation may reduce the risk of abnormal pregnancy outcomes. Intriguingly, FA may have a beneficial effect on
Giulia Paci et al.
eLife, 9 (2020-07-22)
Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC). Among the thousands of molecules that cross the NPC, even very large (>15 nm) cargoes such as pathogens, mRNAs and pre-ribosomes can pass the NPC intact. For these cargoes
Xing-Ding Zhang et al.
PloS one, 8(5), e63245-e63245 (2013-05-23)
We have previously reported that the mitochondria inhibitor 3-nitropropionic acid (3-NP), induces the expression of DNA damage-regulated autophagy modulator1 (DRAM1) and activation of autophagy in rat striatum. Although the role of DRAM1 in autophagy has been previously characterized, the detailed

商品

包括FITC-葡聚糖、FITC-DEAE-葡聚糖(FDD)、FITC-羧甲基 - 葡聚糖(FCM-葡聚糖)在内的FITC标记多糖的补充信息。本页面主要介绍了重均分子量对于对应分子尺寸和其他物理性质的影响

Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.

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