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Merck
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文件

486R-1

Sigma-Aldrich

Somatostatin Receptor 2A (EP149) Rabbit Monoclonal Primary Antibody

别名:

SSTR2A

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About This Item

分類程式碼代碼:
41116161

生物源

rabbit

品質等級

500

共軛

unconjugated

抗體表格

IgG fraction of antiserum

抗體產品種類

primary antibodies

無性繁殖

EP149

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL (concentrate (486R-14))
vial of 0.1 mL (concentrate (486R-14-RUO) Research Use Only)
vial of 0.5 mL (concentrate (486R-15))
vial of 1.0 mL (concentrate (486R-16))
vial of 1.0 mL (concentrate (486R-16-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute (486R-17-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute ready-to-use (486R-17))
vial of 7.0 mL (pre-dilute ready-to-use (486R-18))
vial of 7.0 mL (pre-dilute ready-to-use (486R-18-RUO) Research Use Only)

製造商／商標名

Cell Marque™

技術

immunohistochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:25-1:100 (concentrated))

同型

IgG

控制

lymph node, pancreas, (meningioma)

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

cytoplasmic (
), membranous

一般說明

Somatostatin Receptor 2A (SSTR2A) is a protein highly expressed in pancreas binding somatostatin and inhibiting pancreatic enzyme secretion. SSTR2A is used as a marker for identifying meningioma from other spindle-cell tumors such as solitary fibrous tumor. SSTR2A is more frequently expressed in higher grade meningiomas and associated to its microvessel proliferation. SSTR2A has demonstrated utility as a diagnostic marker for follicular dendritic cell sarcomas and some other related tumors.

品質

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

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Camille Boulagnon-Rombi et al.
Journal of neuropathology and experimental neurology, 76(4), 289-298 (2017-03-25)
The differential diagnosis between meningioma and others tumors can be challenging. This study aimed to evaluate different immunohistochemical markers for the differential diagnosis between meningioma and their morphological mimics. Immunohistochemistry was performed on tissue microarray with antiepithelial membrane antigen (EMA)
Li-Li Tao et al.
The American journal of surgical pathology, 43(3), 374-381 (2018-12-27)
SSTR2a, a member of the somatostatin receptor family, has been used as a diagnostic marker of meningioma. However, the expression of SSTR2a in follicular dendritic cells (FDCs) and their related tumors has been poorly characterized. This study aimed to assess
V Barresi et al.
Oncology reports, 20(3), 485-492 (2008-08-13)
Somatostatin anti-proliferative and anti-angiogenic activities, together with the expression of somatostatin receptors (sstrs), account for the use of somatostatin analogues in the treatment of human tumours. In the present study, sstr2A immunohistochemical expression was analyzed in grade II and III
Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen.
Joshua R Menke et al.
Acta neuropathologica, 130(3), 441-443 (2015-07-22)
Balrik Kailey et al.
American journal of physiology. Endocrinology and metabolism, 303(9), E1107-E1116 (2012-08-31)
Somatostatin-14 (SST) inhibits insulin and glucagon secretion by activating G protein-coupled somatostatin receptors (SSTRs), of which five isoforms exist (SSTR1-5). In mice, the effects on pancreatic β-cells are mediated by SSTR5, whereas α-cells express SSTR2. In both cell types, SSTR

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