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Merck
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文件

478M-9

Sigma-Aldrich

CDK4 (DCS-31) Mouse Monoclonal Antibody

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About This Item

分類程式碼代碼:
12352203

生物源

mouse

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

DCS-31, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (478M-94)
vial of 0.1 mL concentrate Research Use Only (478M-94-RUO)
vial of 0.5 mL concentrate (478M-95)
vial of 1.0 mL concentrate (478M-96)
vial of 1.0 mL concentrate Research Use Only (478M-96-RUO)
vial of 1.0 mL pre-dilute Research Use Only (478M-97-RUO)
vial of 1.0 mL pre-dilute ready-to-use (478M-97)
vial of 7.0 mL pre-dilute ready-to-use (478M-98)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (478M-98-RUO)

製造商／商標名

Cell Marque™

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

同型

IgG

控制

dedifferentiated liposarcoma, well-differentiated liposarcoma

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

nuclear

相关类别

一般說明

Well-differentiated liposarcoma is a malignant, non-metastasizing tumor that can present with similar histological characteristics as benign lipoma lesions and has a higher recurrence rate. The CDK4 protein is frequently overexpressed in well-differentiated liposarcoma due to gene amplification of the 12q13-15 chromosomal region that harbors the CDK4 gene, but amplification and subsequent overexpression is rarely observed in lipomas. Due to CDK4 protein expression differences between these lesions, anti-CDK4 antibody can be used in an immunohistochemistry panel as an aid in the differential diagnosis between well-differentiated liposarcoma and lipoma.1,2,3

品質

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

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其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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P B Aleixo et al.
Journal of clinical pathology, 62(12), 1127-1135 (2009-12-01)
Well differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) have been shown to have supernumerary chromosomes with amplified sequences of the MDM2 and CDK4 genes. MDM2 and CDK4 protein overexpression have also been identified in these tumours. To investigate whether immunohistochemistry
Matthieu Bui Nguyen Binh et al.
The American journal of surgical pathology, 29(10), 1340-1347 (2005-09-15)
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) may be difficult to distinguish from benign adipose tumors and from poorly differentiated sarcomas, respectively. Genetically, they are characterized by amplification of MDM2 and CDK4 genes on chromosome 12q13-15. We examined
Khin Thway et al.
The American journal of surgical pathology, 36(3), 462-469 (2012-02-04)
Adipocytic tumors are the most common type of soft tissue neoplasms. Distinguishing atypical lipomatous tumor-well-differentiated liposarcoma (WDL) from benign adipocytic neoplasms and dedifferentiated liposarcoma (DDL) from pleomorphic or myxoid liposarcoma (LPS) can be difficult. WDL and DDL characteristically harbor amplifications

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