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Merck
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文件

261M-9

Sigma-Aldrich

磷脂酰肌醇聚糖-3 (1G12)

clone 1G12, unconjugated, Cell Marque™

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

1G12, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (261M-94)
vial of 0.5 mL concentrate (261M-95)
bottle of 1.0 mL predilute (261M-97)
vial of 1.0 mL concentrate (261M-96)
bottle of 7.0 mL predilute (261M-98)

製造商／商標名

Cell Marque™

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

同型

IgG1

控制

hepatocellular carcinoma (HCC)

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

cytoplasmic

基因資訊

human ... GPC3(2719)

一般說明

磷脂酰肌醇蛋白聚糖3（GPC3）是一种膜结合硫酸肝素蛋白聚糖，可参与细胞生长和分化。GPC3的表达见于大多数肝细胞癌（HCC），但是在非肿瘤肝组织中非常少见，这使其成为有用的HCC标记物。此外，这种标记物在许多卵黄囊瘤中表达。

品質


IVD
IVD
IVD
RUO

聯結

磷脂酰肌醇聚糖-3阳性对照玻片，产品编号261S，可用于免疫组化（福尔马林固定、石蜡包埋的切片）。

外觀

溶于Tris缓冲液中的溶液（pH 7.3-7.7），含1％BSA和 <0.1％叠氮化钠

準備報告

下载针对您的产品批次和规格的使用说明书(IFU)注意：该过程需要可在包装或产品标签上找到的密钥代码。

其他說明

有关技术服务，请联系： 800-665-7284或电子邮件：service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Debra L Zynger et al.
The American journal of surgical pathology, 30(12), 1570-1575 (2006-11-24)
Glypican 3 (GPC3), a membrane-bound heparin sulfate proteoglycan, may play a role in promoting embryonic cell growth and differentiation. GPC3 is mutated in Simpson-Golabi-Behmel syndrome, characterized by tissue overgrowth and an increased risk of embryonal malignancies. Recently, GPC3 was reported
Dina H Kandil et al.
Advances in anatomic pathology, 16(2), 125-129 (2009-06-25)
Glypican-3 (GPC3) is a heparan sulfate proteoglycan that plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal
Mariana Capurro et al.
Gastroenterology, 125(1), 89-97 (2003-07-10)
Early detection of hepatocellular carcinoma (HCC) is critical for successful treatment. However, the differential diagnosis between HCC and benign hepatic lesions is sometimes difficult and new biochemical markers for HCC are required. It has been reported that glypican-3 (GPC3) messenger
Dina Kandil et al.
Cancer, 111(5), 316-322 (2007-09-01)
Glypican-3 (GPC3) is a heparan sulfate proteoglycan which is elevated in the serum of patients with hepatocellular carcinoma (HCC), but not in healthy blood donors, or patients with benign liver disease. GPC3 immunohistochemistry (IHC) is a promising marker of HCC
Wanda M P Coston et al.
The American journal of surgical pathology, 32(3), 433-444 (2008-02-28)
Distinguishing a well-differentiated hepatocellular carcinoma (HCC) from normal and cirrhotic liver tissue or benign liver nodules, such as hepatic adenoma (HA) and focal nodular hyperplasia (FNH), may be very difficult in some cases, particularly in small needle core biopsies. We
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