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T7645

Sigma-Aldrich

丁卡因 盐酸盐

Sigma Reference Standard

别名:

4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯, 丁卡因 盐酸盐

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About This Item

经验公式（希尔记法）:
C15H24N2O2 · HCl
CAS号:
136-47-0
分子量:
300.82
MDL號碼:
MFCD00038912
分類程式碼代碼:
12352200
PubChem物質ID:
329826873

等級

Sigma Reference Standard

包裝

vial of 250 mg

溶解度

alcohol: soluble in 40 parts solvent
chloroform: soluble in 30 parts of solvent
H2O: soluble 50 mg/mL, clear, colorless
acetone: insoluble
benzene: insoluble
diethyl ether: insoluble

SMILES 字串

Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI

1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

InChI 密鑰

PPWHTZKZQNXVAE-UHFFFAOYSA-N

基因資訊

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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應用

Tetracaine hydrochloride has been used to analyze Ca2+ release from sarcoplasmic reticulum (SR) in neonatal ventricular cardiomyocytes (NVCMs). Tetracaine hydrochloride has also been used as a component of protease digestion buffers.
眼用局部麻醉药；用于脊髓麻醉

生化／生理作用

阻断 Ca2+ 从肌浆网的电压敏感性释放。

包裝

Supplied in amber screw-cap vials

準備報告

Tetracaine hydrochloride dissolves in water at 50 mg/ml to yield a clear, colorless solution. It is also soluble in 40 parts alcohol and 30 parts chloroform. However, it is practically insoluble in ether benzene or acetone.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301,H319,H336

危險分類

Acute Tox. 3 Oral - Eye Irrit. 2 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析证书(COA)

Lot/Batch Number
014F5965

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A M Knight et al.
European journal of immunology, 22(3), 879-882 (1992-03-01)
Recent reports have shown that both exogenous and endogenous mouse mammary tumor viruses (MMTV) can encode superantigens. Transfection and transgenic studies have identified the open reading frame (ORF) present in the 3' long terminal repeat (LTR) as encoding superantigen function.
Patrick Most et al.
Journal of cell science, 118(Pt 2), 421-431 (2005-01-18)
Calcium is a key regulator of cardiac function and is modulated through the Ca2+-sensor protein S100A1. S100 proteins are considered to exert both intracellular and extracellular functions on their target cells. Here we report the impact of an increased intracellular
Patrick E McCleskey et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(1 Pt 1), 82-91 (2013-01-03)
Few published studies have analyzed serum lidocaine levels and individual patient characteristics affecting metabolism after application of compounded topical anesthetics. To measure serum lidocaine levels during and cutaneous side effects after standardized application of 23% lidocaine/7% tetracaine compounded anesthetic to
Gabriel C Gaviola et al.
The Laryngoscope, 123(4), 852-858 (2013-02-14)
Transnasal endoscopy is commonly performed in an outpatient otolaryngology setting. Patients are typically administered a topical anesthetic and decongestant prior to this procedure to alleviate discomfort and improve visualization. There is no consensus on which topical anesthetic is most effective
K Ruetzler et al.
British journal of anaesthesia, 109(5), 790-796 (2012-07-27)
Arterial catheterization is painful and is associated with patient stress and anxiety. Analgesia is usually provided by subcutaneous injection of local anaesthetic. An alternative is topical anaesthesia, such as Rapydan which is a novel topical anaesthetic patch containing 70 mg
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