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等級
certified reference material
pharmaceutical secondary standard
品質等級
agency
traceable to Ph. Eur. Y0000837
traceable to USP 1680007
API 家族
triamterene
CofA
current certificate can be downloaded
包裝
pkg of 400 mg
技術
HPLC: suitable
gas chromatography (GC): suitable
應用
pharmaceutical (small molecule)
格式
neat
儲存溫度
2-30°C
SMILES 字串
Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
InChI
1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
InChI 密鑰
FNYLWPVRPXGIIP-UHFFFAOYSA-N
基因資訊
human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1G(6340)
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一般說明
Triamterene is a potassium-sparing diuretic, which exhibits antihypertensive activity. It is used in combination with thiazide deuretic, such as benzthiazide for treating hypertension and edema associated with mild to moderate congestive heart failure.
應用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Triamterene may be used as a secondary pharma standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique.
分析報告
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
其他說明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
腳註
To see an example of a Certificate of Analysis for this material enter LRAA7397 in the slot below. This is an example certificate only and may not be the lot that you receive.
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Triamterene and Benzthiazide in Tablets
Chauhan CV, et al.
PharmaTutor, 2(6), 115-122 (2014)
High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms
El-Hay ASS, et al.
Acta pharmaceutica, 66(1), 109-118 (2016)
Xinyu Qi et al.
Nature medicine, 25(8), 1225-1233 (2019-07-25)
Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovulatory dysfunction and polycystic ovaries1, and is often accompanied by insulin resistance2. The mechanism of ovulatory dysfunction and insulin resistance in PCOS remains elusive, thus limiting the development of therapeutics. Improved
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