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Merck

PHR1111

Supelco

甘氨酸

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氨基乙酸, 甘氨酸

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About This Item

线性分子式:
NH2CH2COOH
CAS号:
分子量:
75.07
Beilstein:
635782
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to Ph. Eur. G0450000
traceable to USP 1295800

API 家族

glycine

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-30°C

SMILES 字串

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI 密鑰

DHMQDGOQFOQNFH-UHFFFAOYSA-N

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一般說明

用于质量控制的制药二级标准品,为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

應用

甘氨酸可用作药物参考标准品,通过高效液相色谱(HPLC)和电位传感技术对药物制剂中的分析物进行测定。
这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

脊髓中的抑制性神经递质,NMDA受体的变构调节器。

分析報告

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他說明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。所有关于该 CRM 的信息都可以在分析证书上找到。

腳註

要查看该材料的分析证书示例,请在下面的栏位中输入 LRAA6054。这只是一个示例证书,可能不是您收到的批次。

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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Characteristics of new composite-and classical potentiometric sensors for the determination of pioglitazone in some pharmaceutical formulations.
Mostafa GAE, et al.
Journal of Pharmaceutical and Biomedical Analysis, 48(1), 57-61 (2008)
G Marrubini et al.
Journal of pharmaceutical and biomedical analysis, 47(4-5), 716-722 (2008-04-12)
In the present study, a single HPLC method was developed for the determination of glycine and threonine in cicatrizants. Two different preparations of a cream and an ointment, and the corresponding bandages, onto which the formulations were applied, were studied.
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
Li-Chun Tu et al.
The EMBO journal, 32(24), 3220-3230 (2013-11-12)
Nuclear pore complexes (NPCs) mediate cargo traffic between the nucleus and the cytoplasm of eukaryotic cells. Nuclear transport receptors (NTRs) carry cargos through NPCs by transiently binding to phenylalanine-glycine (FG) repeats on intrinsically disordered polypeptides decorating the NPCs. Major impediments
Suzanne L Grant et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 844(2), 278-282 (2006-08-08)
A simple and versatile methodology using high-performance liquid chromatography (HPLC) with fluorimetric detection was developed to simultaneously determine d-serine along with other metabolically related neuroactive amino acids in the glutamatergic system: L-serine, L-glutamate, L-glutamine, and glycine. On-column sensitivity was in

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