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文件

PHL89156

Alantolactone

Name: Alantolactone
Brand: SIAL

phyproof^® Reference Substance

别名:

(+)-Alantolactone., 3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one, Alant camphor, Elecampane camphor, Eupatal, Inula camphor, NSC 333843, NSC 93131

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About This Item

经验公式（希尔记法）:

C₁₅H₂₀O₂

CAS号:

546-43-0

分子量:

232.32

EC號碼:

208-899-3

MDL號碼:

MFCD00274568

分類程式碼代碼:

41116107

NACRES:

NA.24

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Sigma-Aldrich

Z517240

Aldrich^® jacketed Friedrichs coil condenser

Sigma-Aldrich

Z516104

Schlenk reaction and storage tube

PHL80906

Biacangelicol

Sigma-Aldrich

SML0415

Alantolactone

Sigma-Aldrich

Z517801

Aldrich^® powder funnel

Sigma-Aldrich

Z409308

Aldrich^® Schlaker reaction tube

Supelco

20030-U

ORBO^™ 活性硅胶管

Sigma-Aldrich

SMB01048

Uzarin

SYNF780060

Synthware^™ Squibb separatory funnel with glass stopcock

等級

primary reference standard

產品線

phyproof^® Reference Substance

化驗

≥90.0% (HPLC)

製造商／商標名

PhytoLab

應用

food and beverages

格式

neat

SMILES 字串

C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12

InChI

1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1

InChI 密鑰

PXOYOCNNSUAQNS-AGNJHWRGSA-N

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一般說明

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化／生理作用

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.

法律資訊

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

象形圖

GHS07

訊號詞

Warning

危險聲明

H317

防範說明

P261 - P272 - P280 - P333 + P313 - P362 + P364 - P501

危險分類

Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number

168266

130443842

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Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways.

Xiaomin Dang et al.

Respiratory research, 21(1), 95-95 (2020-04-24)

It is well established that airway remodeling and inflammation are characteristics for chronic obstructive pulmonary disease (COPD). Moreover, cigarette smoke extract (CSE) promots inflammation, apoptosis and oxidative stress in COPD. And, there is evidence suggested that alantolactone (ALT), a sesquiterpene

Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling.

Hsiang-Lai Chen et al.

Pharmaceutical biology, 59(1), 134-145 (2021-02-09)

Alantolactone, the bioactive component in Inula helenium L. (Asteraceae), exhibits multiple biological effects. We aimed to determine the anti-inflammatory effect of alantolactone in a collagen-induced arthritis (CIA) mouse model and its immunomodulatory effects on Th17 differentiation. A CIA mouse model

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Alantolactone