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Merck
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文件

P9672

Supelco

普罗布考

analytical standard

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About This Item

经验公式（希尔记法）:
C31H48O2S2
CAS号:
23288-49-5
分子量:
516.84
EC號碼:
245-560-9
MDL號碼:
MFCD00079281
分類程式碼代碼:
41116107
PubChem物質ID:
329820354
NACRES:
NA.24

等級

analytical standard

品質等級

200

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

SMILES 字串

CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C

InChI

1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3

InChI 密鑰

FYPMFJGVHOHGLL-UHFFFAOYSA-N

基因資訊

human ... ABCA1(19) , IL1B(3553) , IL6(3569) , TNF(7124)

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相关类别

一般說明

Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties. It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).

應用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化／生理作用

提高 HDL 相关胆固醇酯的选择性摄取

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number
SLCR4304
SLCM2132
SLBS3412V
SLBR2496V
MKBQ8447V

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Jonathan Watt et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 81(4), 698-708 (2012-05-15)
The aim of this study was to assess the efficacy of stent-based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Current drugs and polymers used to coat coronary stents remain suboptimal in terms of
Chang-Jiang Ge et al.
Chinese medical journal, 125(14), 2472-2476 (2012-08-14)
The plasma cystatin C concentration (PcyC) has been demonstrated to have prognostic value in acute coronary syndrome, but the study of PcyC in patients with borderline coronary lesions is limited. Moreover, the effects of atorvastatin and probucol on PcyC and
Eduardo Luiz Gasnhar Moreira et al.
Neuroscience letters, 541, 193-198 (2013-03-09)
Epidemiological studies indicate that high midlife plasma cholesterol levels increases the risk of Alzheimer's disease. Moreover, middle-aged familial hypercholesterolemia (FH) subjects show a particularly high incidence of mild cognitive impairments (MCI). These evidence points to hypercholesterolemia as one of the
Ryusuke Takechi et al.
Clinical and experimental pharmacology & physiology, 40(1), 45-52 (2012-11-22)
Dysfunction of the blood-brain barrier (BBB) is an early pathological feature of vascular dementia and Alzheimer's disease (AD) and is triggered by inflammatory stimuli. Probucol is a lipid-lowering agent with potent anti-oxidant properties once commonly used for the treatment of
Rong Wu et al.
Digestive diseases and sciences, 58(1), 163-171 (2012-08-11)
We sought to evaluate the effects of probucol on steatohepatitis and associated molecular mechanisms in a rat model of nonalcoholic steatohepatitis (NASH) induced by high-fat diet (HFD). Forty male rats weighing 100-120 g were randomly assigned to the following treatments (n = 10
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商品

胆固醇的运输

由于胆固醇是水不溶性分子，必须包装后才能在血浆中运输。包装胆固醇、胆固醇酯和甘油三酯以便运输的颗粒称为脂蛋白。

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

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