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About This Item
经验公式（希尔记法）:
C17H22N4O · 2HCl
CAS号:
分子量:
371.30
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24
推荐产品
等級
analytical standard
品質等級
技術
HPLC: suitable
gas chromatography (GC): suitable
應用
forensics and toxicology
pharmaceutical (small molecule)
形式
neat
SMILES 字串
Cl.Cl.Cc1cc(nnc1NCCN2CCOCC2)-c3ccccc3
InChI
1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H
InChI 密鑰
GNUCGROXDZMCJI-UHFFFAOYSA-N
基因資訊
human ... ACHE(43) , CHRM1(1128) , DRD2(1813) , HTR2B(3357) , HTR2C(3358) , MAOA(4128) , SLC6A4(6532)
rat ... Ache(83817) , Camk2a(25400) , Prkca(24680)
應用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化／生理作用
抗抑郁剂
C A Lorenzini et al.
Pharmacology, biochemistry, and behavior, 45(2), 481-485 (1993-06-01)
The nootropic activity of 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl-pyridazine dihydrochloride (minaprine) has been investigated in intact male, adult Long Evans rats by means of an active avoidance paradigm. In the light-dark box apparatus, the rat had to learn the active avoidance response of going
A Imperato et al.
Neuroscience letters, 166(1), 69-72 (1994-01-17)
Subchronic (5 mg/kg daily for 9 consecutive days) but not acute minaprine treatment enhanced in vivo dopamine release in the limbic part of the striatum of rats as revealed by intracerebral microdialysis. Moreover, the same subchronic treatment with minaprine reduced
H Allain et al.
Therapie, 51(2), 155-162 (1996-03-01)
Thirty five subjects (age: 45-69 years) with subjective memory loss, without any other neuropsychiatric or somatic disease, were recruited in a phase II study. This double blind randomized versus placebo controlled study compared the effects of minaprine (200 mg/d) with
T R Norman et al.
The Australian and New Zealand journal of psychiatry, 26(1), 73-81 (1992-03-01)
A review of the clinical efficacy of four structurally distinct antidepressant drugs is presented. Their antidepressant activity can be rationalised within current pharmacological hypotheses of drug action, despite markedly different effects on "in vitro" testing. Fluoxetine, a specific serotonin re-uptake
Y Karasawa et al.
Physiology & behavior, 52(1), 141-147 (1992-07-01)
We attempted to determine if the cholinomimetic activity of the psychotropic drug minaprine was related to the amelioration of the delayed neuronal death induced by cerebral ischemia in Mongolian gerbils. Minaprine improved the passive avoidance deficit induced by cerebral ischemia
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