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product name
4-(2-[6-(二辛基氨基)-2-萘基]乙烯基)-1-(3-磺丙基)吡啶鎓 内盐, ≥95% (HPLC), solid
品質等級
化驗
≥95% (HPLC)
形狀
solid
分子量
592.88
顏色
orange to red
溶解度
DMSO: soluble
ethanol: soluble
&epsilon ;(消光係數)
≥37 at 495-501 nm in methanol
螢光
λex 710-716 nm
應用
diagnostic assay manufacturing
hematology
histology
儲存溫度
2-8°C
SMILES 字串
CCCCCCCCN(CCCCCCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1
InChI
1S/C36H52N2O3S/c1-3-5-7-9-11-13-25-38(26-14-12-10-8-6-4-2)36-21-20-34-30-33(18-19-35(34)31-36)17-16-32-22-27-37(28-23-32)24-15-29-42(39,40)41/h16-23,27-28,30-31H,3-15,24-26,29H2,1-2H3
InChI 密鑰
IXFSUSNUALIXLU-UHFFFAOYSA-N
生化/生理作用
一种快速响应的膜电位染料。
聯結
可在细胞质膜外叶滞留更久,因此比di-4-ANEPPS(货号D8064)更适合长时程膜电位研究。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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Ventricular myocytes (VM) depolarization activates L-type Ca2+ channels (LCC) allowing Ca2+ influx (ICa) to synchronize sarcoplasmic reticulum (SR) Ca2+ release, via Ca2+-release channels (RyR2). The resulting whole-cell Ca2+ transient triggers contraction, while cytosolic Ca2+ removal by SR Ca2+ pump (SERCA2)
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Cardiovascular research, 115(3), 556-569 (2018-09-01)
Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced cell death. In contrast, the role played by SR Ca2+ uptake under
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